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    Grap GRB2-related adaptor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grapprovided by RGD
    Official Full Name
    GRB2-related adaptor proteinprovided by RGD
    Primary source
    RGD:1306884
    See related
    EnsemblRapid:ENSRNOG00000002599 AllianceGenome:RGD:1306884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade; sensory perception of sound; and signal transduction. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114. Orthologous to human GRAP (GRB2 related adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 317.9), Spleen (RPKM 150.9) and 4 other tissues See more
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    Genomic context

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    See Grap in Genome Data Viewer
    Location:
    10q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46798423..46851524)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46298965..46352057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47930633..47949774)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene epsin 2 Neighboring gene transfer RNA valine (anticodon AAC) 10 Neighboring gene uncharacterized LOC134480802 Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. Li C, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30610177, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112733

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-related adapter protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025749.1 → NP_001020920.1  GRB2-related adapter protein

      See identical proteins and their annotated locations for NP_001020920.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098740
      UniProtKB/TrEMBL
      Q4KM68
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11948
      Location:2 → 55
      SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
      cl17036
      Location:162 → 214
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46798423..46851524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269509.1 → XP_063125579.1  GRB2-related adapter protein isoform X1

      Related
      ENSRNOP00000003515.4, ENSRNOT00000003515.6

    2. XM_039086467.2 → XP_038942395.1  GRB2-related adapter protein isoform X2

      UniProtKB/TrEMBL
      Q4KM68
      Conserved Domains (3) summary
      cd09941
      Location:56 → 150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11948
      Location:2 → 55
      SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
      cl17036
      Location:162 → 214
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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