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    Mmrn1 multimerin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mmrn1provided by RGD
    Official Full Name
    multimerin 1provided by RGD
    Primary source
    RGD:1587248
    See related
    EnsemblRapid:ENSRNOG00000024986 AllianceGenome:RGD:1587248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable extracellular matrix constituent conferring elasticity. Predicted to be involved in cell adhesion mediated by integrin; negative regulation of wound healing; and positive regulation of platelet aggregation. Predicted to be located in collagen-containing extracellular matrix; extracellular region; and platelet alpha granule. Predicted to be part of multimerin complex. Orthologous to human MMRN1 (multimerin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 80.1), Lung (RPKM 73.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmrn1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (91205462..91280862)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (89875408..89950814)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (90977537..91038747)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene synuclein alpha Neighboring gene enolase 1, pseudogene 7 Neighboring gene protein phosphatase 6, catalytic subunit, pseuidogene 1 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of multimerin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    multimerin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427207.1 → NP_001414136.1  multimerin-1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6KF09, D4A3E0
      Related
      ENSRNOP00000035433.4, ENSRNOT00000030320.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      91205462..91280862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236596.5 → XP_006236658.1  multimerin-1 isoform X2

      See identical proteins and their annotated locations for XP_006236658.1

      Conserved Domains (4) summary
      cd00054
      Location:1026 → 1058
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR04523
      Location:311 → 851
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam07546
      Location:195 → 262
      EMI; EMI domain
      cl23878
      Location:1075 → 1209
      C1q; C1q domain

    2. XM_001071128.8 → XP_001071128.2  multimerin-1 isoform X1

      See identical proteins and their annotated locations for XP_001071128.2

      UniProtKB/TrEMBL
      A6KF09, D4A3E0
      Conserved Domains (4) summary
      cd00054
      Location:1027 → 1059
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      TIGR04523
      Location:311 → 851
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam07546
      Location:195 → 262
      EMI; EMI domain
      cl23878
      Location:1076 → 1210
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version

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