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    Pfas phosphoribosylformylglycinamidine synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfasprovided by RGD
    Official Full Name
    phosphoribosylformylglycinamidine synthaseprovided by RGD
    Primary source
    RGD:1304926
    See related
    EnsemblRapid:ENSRNOG00000005193 AllianceGenome:RGD:1304926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphoribosylformylglycinamidine synthase activity. Involved in glutamine metabolic process and response to xenobiotic stimulus. Predicted to be active in cytoplasm. Biomarker of hepatocellular carcinoma. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 104.8), Spleen (RPKM 89.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pfas in Genome Data Viewer
    Location:
    10q24
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54189157..54210685, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53690301..53711811, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55571881..55593384, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 15 Neighboring gene uncharacterized LOC134480814 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor Neighboring gene small nucleolar RNA SNORA7 Neighboring gene CST telomere replication complex component 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proliferation-linked increase in phosphoribosylformylglycinamidine synthetase activity (EC 6.3.5.3). Elliott WL, et al. Cancer Res, 1984 Jun. PMID 6722784
    2. Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin. Weber G, et al. Adv Enzyme Regul, 1984. PMID 6206692
    3. Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis. Patterson D, et al. Gene, 1999 Nov 1. PMID 10548741
    4. Purification and characterization of GMP synthetase from Yoshida sarcoma ascites cells. Hirai K, et al. J Biochem, 1987 Oct. PMID 3436958
    5. Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase in neurons. Mangold CA, et al. J Neurochem, 2018 Mar. PMID 29337348, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 'de novo' XMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within anterior head development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoribosylformylglycinamidine synthase
    Names
    FGAM synthetase
    phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
    NP_001382026.1
    XP_006246672.1
    XP_006246673.1
    XP_006246674.1
    XP_063124702.1
    XP_063124703.1
    XP_063124704.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395097.1 → NP_001382026.1  phosphoribosylformylglycinamidine synthase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFM5, D4AB17
      Related
      ENSRNOP00000007087.8, ENSRNOT00000007087.9
      Conserved Domains (1) summary
      TIGR01735
      Location:7 → 1332
      FGAM_synt; phosphoribosylformylglycinamidine synthase, single chain form

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54189157..54210685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246611.5 → XP_006246673.1  phosphoribosylformylglycinamidine synthase isoform X2

      See identical proteins and their annotated locations for XP_006246673.1

      UniProtKB/TrEMBL
      A6HFM5
      Conserved Domains (4) summary
      cd02203
      Location:162 → 552
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:650 → 924
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      TIGR01735
      Location:2 → 1276
      FGAM_synt; phosphoribosylformylglycinamidine synthase, single chain form
      pfam13507
      Location:1006 → 1275
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain

    2. XM_006246610.5 → XP_006246672.1  phosphoribosylformylglycinamidine synthase isoform X1

      UniProtKB/TrEMBL
      A6HFM5, D4AB17
      Conserved Domains (1) summary
      TIGR01735
      Location:7 → 1332
      FGAM_synt; phosphoribosylformylglycinamidine synthase, single chain form

    3. XM_006246612.5 → XP_006246674.1  phosphoribosylformylglycinamidine synthase isoform X2

      See identical proteins and their annotated locations for XP_006246674.1

      UniProtKB/TrEMBL
      A6HFM5
      Conserved Domains (4) summary
      cd02203
      Location:162 → 552
      PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      cd02204
      Location:650 → 924
      PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
      TIGR01735
      Location:2 → 1276
      FGAM_synt; phosphoribosylformylglycinamidine synthase, single chain form
      pfam13507
      Location:1006 → 1275
      GATase_5; CobB/CobQ-like glutamine amidotransferase domain

    4. XM_063268632.1 → XP_063124702.1  phosphoribosylformylglycinamidine synthase isoform X1

      UniProtKB/TrEMBL
      A6HFM5, D4AB17

    5. XM_063268633.1 → XP_063124703.1  phosphoribosylformylglycinamidine synthase isoform X1

      UniProtKB/TrEMBL
      A6HFM5, D4AB17

    6. XM_063268634.1 → XP_063124704.1  phosphoribosylformylglycinamidine synthase isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105791.1: Suppressed sequence

      Description
      NM_001105791.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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