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    Fbxl4 F-box and leucine-rich repeat protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxl4provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 4provided by RGD
    Primary source
    RGD:1305724
    See related
    EnsemblRapid:ENSRNOG00000005641 AllianceGenome:RGD:1305724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within autophagy of mitochondrion. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 171.5), Kidney (RPKM 91.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl4 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40752513..40826154)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35955801..36029446)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (36555061..36628920)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102844 Neighboring gene PEST proteolytic signal containing nuclear protein, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102553820 Neighboring gene POU class 3 homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. Gai X, et al. Am J Hum Genet, 2013 Sep 5. PMID 23993194, Free PMC Article
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395576.1 → NP_001382505.1  F-box/LRR-repeat protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWF5, B1WBR8, F7FMX3
      Related
      ENSRNOP00000057843.2, ENSRNOT00000061128.6
      Conserved Domains (3) summary
      cd09293
      Location:394 → 601
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    2. NM_001395577.1 → NP_001382506.1  F-box/LRR-repeat protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWF5, A0A8I5Y8W0
      Related
      ENSRNOP00000076415.1, ENSRNOT00000102239.2
      Conserved Domains (3) summary
      cd09293
      Location:394 → 577
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:295 → 317
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    RNA

    1. NR_172642.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      40752513..40826154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593343.2 → XP_017448832.1  F-box/LRR-repeat protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWF5, B1WBR8, F7FMX3
      Conserved Domains (3) summary
      cd09293
      Location:394 → 601
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    2. XM_063287583.1 → XP_063143653.1  F-box/LRR-repeat protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWF5, A0A8I5Y8W0

    3. XM_039109815.1 → XP_038965743.1  F-box/LRR-repeat protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWF5, B1WBR8, F7FMX3
      Conserved Domains (3) summary
      cd09293
      Location:394 → 601
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    4. XM_017593342.2 → XP_017448831.1  F-box/LRR-repeat protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWF5, B1WBR8, F7FMX3
      Conserved Domains (3) summary
      cd09293
      Location:394 → 601
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:347 → 376
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:280 → 318
      F-box-like

    5. XM_063287582.1 → XP_063143652.1  F-box/LRR-repeat protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWF5, A0A8I5Y8W0
    Nucleotide Protein Strain
    Heading Accession and Version

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