Spata2 spermatogenesis associated 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spata2provided by RGD
Official Full Name: spermatogenesis associated 2provided by RGD
Primary source: RGD:620754
See related: EnsemblRapid:ENSRNOG00000009207 AllianceGenome:RGD:620754
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within seminiferous tubule development and spermatogenesis. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 84.1), Thymus (RPKM 60.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176621974..176639784, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (156202962..156213283, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (164229211..164239483, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spata2 Knockdown Exacerbates Brain Inflammation via NF-kappaB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
Title: Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein linear deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein linear deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within seminiferous tubule development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: spermatogenesis-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429657.1 → NP_001416586.1 spermatogenesis-associated protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

F1LNA7, Q66HP6, Q91XS7
NM_001429658.1 → NP_001416587.1 spermatogenesis-associated protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

F1LNA7, Q66HP6, Q91XS7
NM_053675.3 → NP_446127.3 spermatogenesis-associated protein 2

See identical proteins and their annotated locations for NP_446127.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

F1LNA7, Q66HP6, Q91XS7

Related

ENSRNOP00000012604.5, ENSRNOT00000012604.6

Conserved Domains (1) summary

cd19757
Location:451 → 494

Bbox1; B-box-type 1 zinc finger (Bbox1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

176621974..176639784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235636.5 → XP_006235698.1 spermatogenesis-associated protein 2 isoform X1

Conserved Domains (1) summary

cd19757
Location:451 → 494

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_039104093.2 → XP_038960021.1 spermatogenesis-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

F1LNA7, Q66HP6, Q91XS7

Conserved Domains (1) summary

cd19757
Location:451 → 494

Bbox1; B-box-type 1 zinc finger (Bbox1)
XM_039104092.2 → XP_038960020.1 spermatogenesis-associated protein 2 isoform X1

Conserved Domains (1) summary

cd19757
Location:451 → 494

Bbox1; B-box-type 1 zinc finger (Bbox1)