Knl1 kinetochore scaffold 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Knl1provided by RGD
Full Name: kinetochore scaffold 1provided by RGD
Primary source: RGD:1307498
See related: EnsemblRapid:ENSRNOG00000060100 AllianceGenome:RGD:1307498
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Casc5
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in nuclear chromosome segregation; protein localization to kinetochore; and regulation of metaphase/anaphase transition of cell cycle. Predicted to be located in acrosomal vesicle; kinetochore; and nuclear body. Predicted to be part of Knl1/Spc105 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 198.2), Spleen (RPKM 133.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126483498..126545774)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106029627..106091915)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (110847304..110909807)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131249 (e-PCR)
- UniSTS:214532

BI278484 (e-PCR)
- UniSTS:244389

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome orientation in meiotic metaphase I	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiosis I spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Knl1/Spc105 complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinetochore scaffold 1

Names: RAD51 homolog; cancer susceptibility candidate 5; protein CASC5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170594.1 → NP_001164065.1 kinetochore scaffold 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A5F3, D3ZNX2

Related

ENSRNOP00000075477.1, ENSRNOT00000081613.3

Conserved Domains (2) summary

pfam08317
Location:1671 → 1937

Spc7; Spc7 kinetochore protein

cl24005
Location:1797 → 1874

DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

126483498..126545774

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762095.3 → XP_008760317.1 kinetochore scaffold 1 isoform X1

UniProtKB/TrEMBL

D3Z896

Related

ENSRNOP00000050682.5, ENSRNOT00000041727.6

Conserved Domains (2) summary

pfam08317
Location:1713 → 1979

Spc7; Spc7 kinetochore protein

cl24005
Location:1839 → 1916

DUF2570; Protein of unknown function (DUF2570)