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    Ncor2 nuclear receptor co-repressor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360801, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ncor2provided by RGD
    Official Full Name
    nuclear receptor co-repressor 2provided by RGD
    Primary source
    RGD:1310293
    See related
    EnsemblRapid:ENSRNOG00000001004 AllianceGenome:RGD:1310293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity; nuclear glucocorticoid receptor binding activity; and nuclear retinoid X receptor binding activity. Involved in several processes, including estrous cycle; lactation; and response to estradiol. Located in chromatin. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 91.5), Spleen (RPKM 47.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncor2 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37127736..37289612)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31466418..31628319)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (36871917..37033701)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481291 Neighboring gene scavenger receptor class B, member 1 Neighboring gene uncharacterized LOC120095963 Neighboring gene uncharacterized LOC120095965 Neighboring gene refilin A Neighboring gene zinc finger protein 664 Neighboring gene ribosomal protein L27 like 5

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear glucocorticoid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell proliferation in forebrain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrous cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in random inactivation of X chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within type I pneumocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear receptor corepressor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108334.1NP_001101804.1  nuclear receptor corepressor 2

      See identical proteins and their annotated locations for NP_001101804.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J0X3, D3ZXN9
      Conserved Domains (4) summary
      smart00717
      Location:610655
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:610653
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:142228
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37127736..37289612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249305.5XP_006249367.1  nuclear receptor corepressor 2 isoform X24

      UniProtKB/TrEMBL
      D3ZXN9
      Conserved Domains (6) summary
      PHA03247
      Location:19172321
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:156411
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG5259
      Location:539649
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam00249
      Location:614657
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:141229
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. XM_006249320.5XP_006249382.1  nuclear receptor corepressor 2 isoform X42

      UniProtKB/TrEMBL
      D3ZXN9
      Conserved Domains (4) summary
      smart00717
      Location:614659
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:614657
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:142228
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. XM_017598397.3XP_017453886.1  nuclear receptor corepressor 2 isoform X44

      UniProtKB/TrEMBL
      A0A0G2JU91, D3ZXN9
      Related
      ENSRNOP00000001334.5, ENSRNOT00000001334.8
    4. XM_017598398.3XP_017453887.1  nuclear receptor corepressor 2 isoform X45

      UniProtKB/TrEMBL
      D3ZXN9
      Related
      ENSRNOP00000069011.3, ENSRNOT00000084236.3
    5. XM_063271518.1XP_063127588.1  nuclear receptor corepressor 2 isoform X25

      UniProtKB/TrEMBL
      D3ZXN9
    6. XM_039089593.2XP_038945521.1  nuclear receptor corepressor 2 isoform X43

      UniProtKB/TrEMBL
      D3ZXN9
      Conserved Domains (6) summary
      PHA03247
      Location:17572258
      PHA03247; large tegument protein UL36; Provisional
      COG5259
      Location:538648
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      TIGR02169
      Location:159404
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00249
      Location:613656
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:141229
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:431474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    7. XM_039089594.2XP_038945522.1  nuclear receptor corepressor 2 isoform X46

      UniProtKB/TrEMBL
      A0A8I6AN60
      Conserved Domains (6) summary
      PHA03247
      Location:17572258
      PHA03247; large tegument protein UL36; Provisional
      COG5259
      Location:538648
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      TIGR02169
      Location:159404
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00249
      Location:613656
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:141229
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:431474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    8. XM_063271525.1XP_063127595.1  nuclear receptor corepressor 2 isoform X33

      UniProtKB/TrEMBL
      A0A8I6GHM0
    9. XM_063271499.1XP_063127569.1  nuclear receptor corepressor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GHM0
    10. XM_063271502.1XP_063127572.1  nuclear receptor corepressor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GHM0
    11. XM_063271507.1XP_063127577.1  nuclear receptor corepressor 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6GHM0
    12. XM_063271513.1XP_063127583.1  nuclear receptor corepressor 2 isoform X20

      UniProtKB/TrEMBL
      A0A8I6GHM0
    13. XM_063271508.1XP_063127578.1  nuclear receptor corepressor 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I6GHM0
    14. XM_063271519.1XP_063127589.1  nuclear receptor corepressor 2 isoform X26

      UniProtKB/TrEMBL
      A0A8I6GHM0
    15. XM_063271506.1XP_063127576.1  nuclear receptor corepressor 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6GHM0
    16. XM_063271514.1XP_063127584.1  nuclear receptor corepressor 2 isoform X21

      UniProtKB/TrEMBL
      A0A8I6GHM0
    17. XM_063271521.1XP_063127591.1  nuclear receptor corepressor 2 isoform X29

      UniProtKB/TrEMBL
      A0A8I6GHM0
    18. XM_063271517.1XP_063127587.1  nuclear receptor corepressor 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I6GHM0
    19. XM_063271523.1XP_063127593.1  nuclear receptor corepressor 2 isoform X31

      UniProtKB/TrEMBL
      A0A8I6GHM0
    20. XM_063271524.1XP_063127594.1  nuclear receptor corepressor 2 isoform X32

      UniProtKB/TrEMBL
      A0A8I6GHM0
    21. XM_063271501.1XP_063127571.1  nuclear receptor corepressor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GHM0
    22. XM_063271515.1XP_063127585.1  nuclear receptor corepressor 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6GHM0
    23. XM_063271522.1XP_063127592.1  nuclear receptor corepressor 2 isoform X30

      UniProtKB/TrEMBL
      A0A8I6GHM0
    24. XM_063271498.1XP_063127568.1  nuclear receptor corepressor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GHM0
    25. XM_063271503.1XP_063127573.1  nuclear receptor corepressor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GHM0
    26. XM_063271509.1XP_063127579.1  nuclear receptor corepressor 2 isoform X16

      UniProtKB/TrEMBL
      A0A8I6GHM0
    27. XM_063271504.1XP_063127574.1  nuclear receptor corepressor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I6GHM0
    28. XM_063271511.1XP_063127581.1  nuclear receptor corepressor 2 isoform X18

      UniProtKB/TrEMBL
      A0A8I6GHM0
    29. XM_017598392.3XP_017453881.1  nuclear receptor corepressor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GHM0
    30. XM_063271512.1XP_063127582.1  nuclear receptor corepressor 2 isoform X19

      UniProtKB/TrEMBL
      A0A8I6GHM0
    31. XM_017598396.3XP_017453885.1  nuclear receptor corepressor 2 isoform X28

      UniProtKB/TrEMBL
      A0A8I6GHM0
    32. XM_039089589.2XP_038945517.1  nuclear receptor corepressor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GHM0
      Conserved Domains (6) summary
      PHA03247
      Location:17412145
      PHA03247; large tegument protein UL36; Provisional
      COG5259
      Location:364474
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      TIGR02169
      Location:5283
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam00249
      Location:439482
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:154
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:257300
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    33. XM_017598391.3XP_017453880.1  nuclear receptor corepressor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHM0
    34. XM_063271510.1XP_063127580.1  nuclear receptor corepressor 2 isoform X17

      UniProtKB/TrEMBL
      A0A8I6GHM0
      Related
      ENSRNOP00000089758.1, ENSRNOT00000104620.2
    35. XM_063271520.1XP_063127590.1  nuclear receptor corepressor 2 isoform X27

      UniProtKB/TrEMBL
      A0A8I6GHM0
    36. XM_063271505.1XP_063127575.1  nuclear receptor corepressor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6GHM0
    37. XM_063271500.1XP_063127570.1  nuclear receptor corepressor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GHM0
    38. XM_063271497.1XP_063127567.1  nuclear receptor corepressor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GHM0
    39. XM_063271527.1XP_063127597.1  nuclear receptor corepressor 2 isoform X35

    40. XM_063271528.1XP_063127598.1  nuclear receptor corepressor 2 isoform X36

    41. XM_039089591.2XP_038945519.1  nuclear receptor corepressor 2 isoform X24

      UniProtKB/TrEMBL
      D3ZXN9
      Conserved Domains (6) summary
      PHA03247
      Location:19172321
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:156411
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG5259
      Location:539649
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam00249
      Location:614657
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:141229
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    42. XM_017598394.3XP_017453883.1  nuclear receptor corepressor 2 isoform X24

      UniProtKB/TrEMBL
      D3ZXN9
      Conserved Domains (6) summary
      PHA03247
      Location:19172321
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:156411
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG5259
      Location:539649
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam00249
      Location:614657
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:141229
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl21498
      Location:432475
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    43. XM_063271526.1XP_063127596.1  nuclear receptor corepressor 2 isoform X34

      UniProtKB/TrEMBL
      A6J0X4
    44. XM_039089592.2XP_038945520.1  nuclear receptor corepressor 2 isoform X37

      UniProtKB/TrEMBL
      A6J0X4
      Conserved Domains (2) summary
      PHA03247
      Location:13071711
      PHA03247; large tegument protein UL36; Provisional
      pfam00249
      Location:1947
      Myb_DNA-binding; Myb-like DNA-binding domain
    45. XM_063271529.1XP_063127599.1  nuclear receptor corepressor 2 isoform X38

      UniProtKB/TrEMBL
      A6J0X4
    46. XM_063271530.1XP_063127600.1  nuclear receptor corepressor 2 isoform X39

      UniProtKB/TrEMBL
      A6J0X4
    47. XM_063271531.1XP_063127601.1  nuclear receptor corepressor 2 isoform X40

      UniProtKB/TrEMBL
      A6J0X4
    48. XM_063271532.1XP_063127602.1  nuclear receptor corepressor 2 isoform X41

      UniProtKB/TrEMBL
      A6J0X4