Csrp3 cysteine and glycine rich protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csrp3provided by RGD
Official Full Name: cysteine and glycine rich protein 3provided by RGD
Primary source: RGD:71092
See related: EnsemblRapid:ENSRNOG00000014327 AllianceGenome:RGD:71092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MLP; CRP3
Summary: Enables MRF binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in blood vessel remodeling. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of myotube differentiation. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 3122.4) and Muscle (RPKM 787.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (107664338..107682916, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (98528067..98546647, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (104147205..104166389, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples.
Title: Discriminating aspects of global metabolism of neonatal cardiomyocytes from wild type and KO-CSRP3 rats using proton magnetic resonance spectroscopy of culture media samples.
Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
Title: Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration.
Retinal MLP expression correlates with the morphologic and functional development of cholinergic amacrine cells, suggesting a potential role of this protein in postnatal maturation.
Title: Neuronal expression of muscle LIM protein in postnatal retinae of rodents.
Cardiac overexpression of muscle LIM protein does not modulate the heart's response to various forms of pathological stress.
Title: Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP).
These findings suggest that nucleocytoplasmic shuttling MLP plays an important role in the regulation of the myocyte remodeling and hypertrophy and is required for adaptation to hypertrophic stimuli.
Title: Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein.
CRP3/MLP is primarily expressed in arterial smooth muscle cells and that stretch is the main stimulus for CRP3/MLP induction in veins exposed to arterial haemodynamic conditions.
Title: Induction of CRP3/MLP expression during vein arterialization is dependent on stretch rather than shear stress.
MLP plays a critical role in vascular remodeling.
Title: A role for muscle LIM protein (MLP) in vascular remodeling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128977 (e-PCR)
- UniSTS:212285

Csrp3 (e-PCR), detects polymorphism
- UniSTS:508565

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MRF binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actinin binding	IEA Inferred from Electronic Annotation more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables telethonin binding	IEA Inferred from Electronic Annotation more info
enables telethonin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-tubule organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T-tubule organization	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiac myofibril assembly	IEA Inferred from Electronic Annotation more info
involved_in cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in detection of muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in detection of muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of actin filament severing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C/protein kinase C signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipase C/protein kinase C signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament severing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myotube differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cysteine and glycine-rich protein 3

Names: LIM domain protein, cardiac; cysteine and glycine rich protein 3 N-terminal nuclear localization sequence; cysteine and glycine rich protein 3 c-terminal HA-tagged; cysteine and glycine rich protein 3 lacking the LIM1-domain; cysteine and glycine-rich protein 3 (cardiac LIM protein); cysteine-rich protein 3; muscle LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057144.2 → NP_476485.2 cysteine and glycine-rich protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P50463

UniProtKB/TrEMBL

A0A3S4B5A5, A6JBF3, G3V7U0

Related

ENSRNOP00000019310.3, ENSRNOT00000019311.7

Conserved Domains (2) summary

cd09481
Location:9 → 62

LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

cd09482
Location:120 → 173

LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)