Dgkk diacylglycerol kinase kappa [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dgkkprovided by RGD
Official Full Name: diacylglycerol kinase kappaprovided by RGD
Primary source: RGD:1561510
See related: EnsemblRapid:ENSRNOG00000039323 AllianceGenome:RGD:1561510
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561510
Summary: Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and response to oxidative stress. Predicted to be active in plasma membrane. Orthologous to human DGKK (diacylglycerol kinase kappa). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 19.0) See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (18253849..18385805, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (15581991..15713814, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (16441318..16526046, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_063280457.1 → XP_063136527.1 diacylglycerol kinase kappa isoform X2

UniProtKB/TrEMBL

F1LZW2
XM_039100305.2 → XP_038956233.1 diacylglycerol kinase kappa isoform X1

UniProtKB/TrEMBL

F1LZW2

Related

ENSRNOP00000056998.5, ENSRNOT00000060247.5

Conserved Domains (6) summary

smart00045
Location:971 → 1128

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:605 → 727

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd13274
Location:329 → 423

PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain

pfam05887
Location:79 → 148

Trypan_PARP; Procyclic acidic repetitive protein (PARP)

cd20800
Location:437 → 494

C1_DGK_typeII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type II diacylglycerol kinases

cd20852
Location:511 → 564

C1_DGK_typeII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type II diacylglycerol kinases