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    CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 83716, updated on 4-Jan-2025

    Summary

    Official Symbol
    CRISPLD2provided by HGNC
    Official Full Name
    cysteine rich secretory protein LCCL domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25248
    See related
    Ensembl:ENSG00000103196 MIM:612434; AllianceGenome:HGNC:25248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LGL1; CRISP11; LCRISP2
    Summary
    Predicted to enable glycosaminoglycan binding activity. Involved in face morphogenesis. Located in transport vesicle. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in gall bladder (RPKM 67.9), placenta (RPKM 54.3) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CRISPLD2 in Genome Data Viewer
    Location:
    16q24.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84819985..84909508)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (90886255..90975767)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84853591..84943114)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 10 Neighboring gene uncharacterized LOC124903737 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84769037-84770002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84770003-84770968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11254 Neighboring gene Sharpr-MPRA regulatory region 6565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11255 Neighboring gene Sharpr-MPRA regulatory region 1784 Neighboring gene uncharacterized LOC105371378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84828009-84828510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84837954-84838454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84839622-84840200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84840201-84840777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84869778-84870346 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:84878477-84879206 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:84879989-84880225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84884617-84885118 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:84913207-84914406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84918435-84919058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84919059-84919684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84919685-84920308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84920309-84920933 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:84943761-84943876 Neighboring gene interferon induced transmembrane protein pseudogene Neighboring gene long intergenic non-protein coding RNA 2176

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1257 screens)

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • MGC74865, DKFZp434B044

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycosaminoglycan binding  
    enables heparin binding  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization  
    involved_in face morphogenesis PubMed 
    involved_in lung development  
    Component Evidence Code Pubs
    located_in extracellular exosome PubMed 
    located_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in ficolin-1-rich granule lumen  
    located_in secretory granule lumen  
    located_in transport vesicle  

    General protein information

    Preferred Names
    cysteine-rich secretory protein LCCL domain-containing 2
    Names
    CRISP-11
    LCCL domain-containing cysteine-rich secretory protein 2
    cysteine-rich secretory protein 11
    late gestation lung 1
    testis secretory sperm-binding protein Li 207a
    trypsin inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031476.4 → NP_113664.1  cysteine-rich secretory protein LCCL domain-containing 2 precursor

      See identical proteins and their annotated locations for NP_113664.1

      Status: VALIDATED

      Source sequence(s)
      AC025280, AL136861, BQ015624, DA325436, DB095807, DB260709
      Consensus CDS
      CCDS10949.1
      UniProtKB/Swiss-Prot
      D3DUM0, Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61, Q9H0B8
      UniProtKB/TrEMBL
      A0A140VK80, H3BTI0
      Related
      ENSP00000262424.5, ENST00000262424.10
      Conserved Domains (2) summary
      smart00603
      Location:286 → 370
      LCCL; LCCL domain
      cd05380
      Location:56 → 201
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      84819985..84909508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256190.2 → XP_005256247.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X1

      See identical proteins and their annotated locations for XP_005256247.1

      UniProtKB/Swiss-Prot
      D3DUM0, Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61, Q9H0B8
      UniProtKB/TrEMBL
      A0A140VK80, H3BTI0
      Conserved Domains (2) summary
      smart00603
      Location:286 → 370
      LCCL; LCCL domain
      cd05380
      Location:56 → 201
      SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      90886255..90975767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314093.1 → XP_054170068.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X1

      UniProtKB/TrEMBL
      H3BTI0
    2. XM_054314094.1 → XP_054170069.1  cysteine-rich secretory protein LCCL domain-containing 2 isoform X2

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