Gzmm granzyme M [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gzmmprovided by RGD
Official Full Name: granzyme Mprovided by RGD
Primary source: RGD:620022
See related: EnsemblRapid:ENSRNOG00000030530 AllianceGenome:RGD:620022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables serine-type peptidase activity. Predicted to be involved in apoptotic process and protein maturation. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be active in extracellular space. Orthologous to human GZMM (granzyme M). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 191.2), Lung (RPKM 90.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10661683..10667448, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (10011065..10016841, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12893431..12899004, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327276 (e-PCR)
- UniSTS:180071

RH143874 (e-PCR)
- UniSTS:233120

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granzyme M

Names: RNK-Met-1; granzyme M (lymphocyte met-ase 1); lymphoctye Met-ase 1; met-ase; natural killer cell granular protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057183.1 → NP_476531.1 granzyme M precursor

See identical proteins and their annotated locations for NP_476531.1

Status: VALIDATED

Source sequence(s)

BI278865, DV216119

UniProtKB/Swiss-Prot

Q03238

UniProtKB/TrEMBL

A6K8Y7, G3V726

Related

ENSRNOP00000083530.1, ENSRNOT00000095743.2

Conserved Domains (1) summary

cd00190
Location:27 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10661683..10667448 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263113.1 → XP_063119183.1 granzyme M isoform X1
XM_039078568.2 → XP_038934496.1 granzyme M isoform X2

UniProtKB/Swiss-Prot

Q03238

Related

ENSRNOP00000011086.4, ENSRNOT00000011086.8

Conserved Domains (1) summary

cd00190
Location:26 → 253

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039078569.2 → XP_038934497.1 granzyme M isoform X3

UniProtKB/TrEMBL

A0A8I5ZVJ4

Conserved Domains (1) summary

cd00190
Location:1 → 214

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...