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    Ptp4a2 protein tyrosine phosphatase 4A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85237, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ptp4a2provided by RGD
    Official Full Name
    protein tyrosine phosphatase 4A2provided by RGD
    Primary source
    RGD:619786
    See related
    EnsemblRapid:ENSRNOG00000050044 AllianceGenome:RGD:619786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme inhibitor activity and protein tyrosine phosphatase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in early endosome and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 2304.0), Spleen (RPKM 1128.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptp4a2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147449733..147476739)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142165405..142192412)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148035501..148060752)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene uncharacterized LOC120103178 Neighboring gene uncharacterized LOC134486996 Neighboring gene SPOC domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of a novel rat protein tyrosine phosphatase gene. Carter DA. Biochim Biophys Acta, 1998 Nov 8. PMID 9805001
    2. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase type IVA 2
    Names
    PRL-2
    protein tyrosine phosphatase type IVA, member 2
    protein-tyrosine phosphatase of regenerating liver 2
    NP_445927.2
    XP_017449153.1
    XP_017449154.1
    XP_038966808.1
    XP_038966809.1
    XP_063144583.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053475.2 → NP_445927.2  protein tyrosine phosphatase type IVA 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1
      Related
      ENSRNOP00000064832.1, ENSRNOT00000074415.4
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      147449733..147476739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110880.2 → XP_038966808.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    2. XM_017593665.3 → XP_017449154.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    3. XM_063288513.1 → XP_063144583.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1

    4. XM_039110881.2 → XP_038966809.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2

    5. XM_017593664.3 → XP_017449153.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O88765, Q6P9X4
      UniProtKB/TrEMBL
      A0A8I6G2R3, A6ISM1
      Conserved Domains (1) summary
      cd18536
      Location:1 → 155
      PTP-IVa2; protein tyrosine phosphatase type IVA 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9X4.1 GenPept UniProtKB/Swiss-Prot:Q6P9X4

    Gene LinkOut

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