Slc35b2 solute carrier family 35 member B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc35b2provided by RGD
Official Full Name: solute carrier family 35 member B2provided by RGD
Primary source: RGD:1565318
See related: EnsemblRapid:ENSRNOG00000019900 AllianceGenome:RGD:1565318
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dsm-1
Summary: Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Predicted to be involved in several processes, including chondroitin sulfate biosynthetic process; peptidyl-tyrosine sulfation; and purine ribonucleotide transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and trans-Golgi network. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 61.8), Spleen (RPKM 57.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (22936031..22940114, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (15438594..15442227, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (17823399..17827032, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH131878 (e-PCR)
- UniSTS:215161

RH127542 (e-PCR)
- UniSTS:210852

RH129394 (e-PCR)
- UniSTS:212701

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport	ISO Inferred from Sequence Orthology more info
involved_in 5'-adenylyl sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine sulfation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 3'-phospho 5'-phosphosulfate transporter 1

Names: D-serine modulator-1; solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.