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    C1qtnf4 C1q and TNF related 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311184, updated on 27-Dec-2024

    Summary

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    Official Symbol
    C1qtnf4provided by RGD
    Official Full Name
    C1q and TNF related 4provided by RGD
    Primary source
    RGD:1311006
    See related
    EnsemblRapid:ENSRNOG00000081381 AllianceGenome:RGD:1311006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of cytokine production and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway via STAT; protein phosphorylation; and reduction of food intake in response to dietary excess. Predicted to be active in extracellular space. Orthologous to human C1QTNF4 (C1q and TNF related 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 240.9) and Kidney (RPKM 15.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See C1qtnf4 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97310220..97328818)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (76854368..76872991)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79713580..79718018)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 2 Neighboring gene ribosomal protein S26, pseudogene 9 Neighboring gene mitochondrial carrier 2 Neighboring gene family with sequence similarity 180 member B Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene kelch repeat and BTB domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [C1q and tumor necrosis factor related protein 4 (CTRP4) suppresses caspase-1/IL-1β inflammatory pathway in trophoblasts of rat models with preeclampsia]. Duan L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Nov. PMID 27774931
    2. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. Byerly MS, et al. J Biol Chem, 2014 Feb 14. PMID 24366864, Free PMC Article
    3. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells. Li Q, et al. Cancer Lett, 2011 Sep 28. PMID 21658842
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTRP4 can significantly inhibit the activation of caspase-1/IL-1beta inflammatory pathway, and suppress the pyroptosis of trophoblasts derived from rats with preeclampsia.
      Title: [C1q and tumor necrosis factor related protein 4 (CTRP4) suppresses caspase-1/IL-1β inflammatory pathway in trophoblasts of rat models with preeclampsia].
    2. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
      Title: C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell surface receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reduction of food intake in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 4
    Names
    C1q and tumor necrosis factor related protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107745.1 → NP_001101215.1  complement C1q tumor necrosis factor-related protein 4 precursor

      See identical proteins and their annotated locations for NP_001101215.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6ACA8, A6HN85, B5DF52
      Related
      ENSRNOP00000089610.1, ENSRNOT00000099320.2
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97310220..97328818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104895.2 → XP_038960823.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACA8, A6HN85, B5DF52
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    2. XM_039104894.2 → XP_038960822.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACA8, A6HN85, B5DF52
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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