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    Zfp827 zinc finger protein 827 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291940, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp827provided by RGD
    Official Full Name
    zinc finger protein 827provided by RGD
    Primary source
    RGD:1560620
    See related
    EnsemblRapid:ENSRNOG00000011697 AllianceGenome:RGD:1560620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560620
    Summary
    Predicted to enable NuRD complex binding activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and regulation of DNA-templated transcription. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 55.5), Thymus (RPKM 54.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp827 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (45624849..45791739, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (28720568..28887381, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (32396155..32616648, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550010 Neighboring gene metabolism of cobalamin associated A Neighboring gene similar to human chromosome 4 open reading frame 51 Neighboring gene uncharacterized LOC120098577 Neighboring gene uncharacterized LOC134483636 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NuRD complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of shelterin complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 827

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400944.1 → NP_001387873.1  zinc finger protein 827

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AI01, F1LVT1
      Related
      ENSRNOP00000085193.2, ENSRNOT00000103444.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      45624849..45791739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277886.1 → XP_063133956.1  zinc finger protein 827 isoform X11

      UniProtKB/TrEMBL
      A0A8I6ACV6, F1LVT1
      Related
      ENSRNOP00000015929.9, ENSRNOT00000015929.10

    2. XM_063277880.1 → XP_063133950.1  zinc finger protein 827 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GCK4
      Related
      ENSRNOP00000092352.2, ENSRNOT00000117381.2

    3. XM_039098166.2 → XP_038954094.1  zinc finger protein 827 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GCK4
      Conserved Domains (5) summary
      COG5048
      Location:352 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1149 → 1173
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1134 → 1158
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_063277885.1 → XP_063133955.1  zinc finger protein 827 isoform X10

      UniProtKB/TrEMBL
      F1LVT1

    5. XM_063277882.1 → XP_063133952.1  zinc finger protein 827 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GCK4

    6. XM_063277881.1 → XP_063133951.1  zinc finger protein 827 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GCK4

    7. XM_063277884.1 → XP_063133954.1  zinc finger protein 827 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GCK4

    8. XM_063277887.1 → XP_063133957.1  zinc finger protein 827 isoform X12

    9. XM_039098172.2 → XP_038954100.1  zinc finger protein 827 isoform X9

      UniProtKB/TrEMBL
      F1LVT1
      Conserved Domains (4) summary
      COG5048
      Location:352 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    10. XM_039098168.2 → XP_038954096.1  zinc finger protein 827 isoform X6

      UniProtKB/TrEMBL
      F1LVT1
      Conserved Domains (4) summary
      COG5048
      Location:352 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    11. XM_039098170.2 → XP_038954098.1  zinc finger protein 827 isoform X7

      UniProtKB/TrEMBL
      F1LVT1
      Conserved Domains (4) summary
      COG5048
      Location:352 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    12. XM_039098171.2 → XP_038954099.1  zinc finger protein 827 isoform X8

      UniProtKB/TrEMBL
      F1LVT1
      Related
      ENSRNOP00000108637.1, ENSRNOT00000148138.1
      Conserved Domains (4) summary
      COG5048
      Location:352 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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