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    Rit1 Ras-like without CAAX 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499652, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rit1provided by RGD
    Official Full Name
    Ras-like without CAAX 1provided by RGD
    Primary source
    RGD:1559874
    See related
    EnsemblRapid:ENSRNOG00000064584 AllianceGenome:RGD:1559874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559874
    Summary
    Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in endomembrane system. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 286.4), Heart (RPKM 202.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rit1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176478616..176493269)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174180742..174195455)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188087486..188099444)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 4 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene RNA, U6 small nuclear 632 Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene misato mitochondrial distribution and morphology regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib. Song Z, et al. Cancer Lett, 2019 Sep 28. PMID 31247273
    2. RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis. Feng YF, et al. Cell Death Dis, 2018 Oct 22. PMID 30348939, Free PMC Article
    3. Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia. Cavé H, et al. Eur J Hum Genet, 2016 Aug. PMID 26757980, Free PMC Article
    4. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Yaoita M, et al. Hum Genet, 2016 Feb. PMID 26714497
    5. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049390, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein Rit1
    NP_001383470.1
    NP_001383471.1
    NP_001383477.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396541.1 → NP_001383470.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ABM0, A6J699, A6J6A2
      Conserved Domains (1) summary
      cd04141
      Location:20 → 191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    2. NM_001396542.1 → NP_001383471.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ABM0, A6J699, A6J6A2
      Conserved Domains (1) summary
      cd04141
      Location:20 → 191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    3. NM_001396548.1 → NP_001383477.1  GTP-binding protein Rit1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6ABM0, A6J699, A6J6A2
      Related
      ENSRNOP00000090769.1, ENSRNOT00000099308.2
      Conserved Domains (1) summary
      cd04141
      Location:20 → 191
      Rit_Rin_Ric; Ras-like protein in all tissues (Rit), Ras-like protein in neurons (Rin) and Ras-related protein which interacts with calmodulin (Ric)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176478616..176493269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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