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    Surf4 surfeit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619346, updated on 27-Dec-2024

    Summary

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    Symbol
    Surf4provided by RGD
    Full Name
    surfeit 4provided by RGD
    Primary source
    RGD:1561980
    See related
    EnsemblRapid:ENSRNOG00000005247 AllianceGenome:RGD:1561980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable COPII receptor activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; Golgi organization; and lipoprotein transport. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum exit site. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 927.2), Adrenal (RPKM 775.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Surf4 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30646435..30659641, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10248360..10261537, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5468284..5481447, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD36 Neighboring gene ribosomal protein L7A Neighboring gene SURF1, cytochrome c oxidase assembly factor Neighboring gene surfeit 2 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4 homolog, 3'-5' exonuclease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Mitrovic S, et al. Mol Biol Cell, 2008 May. PMID 18287528, Free PMC Article
    2. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza L, et al. J Biol Chem, 2004 Nov 5. PMID 15308636
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables COPII receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid export from cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of organelle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    surfeit locus protein 4
    Names
    surfeit locus protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033868.1 → NP_001029040.1  surfeit locus protein 4

      See identical proteins and their annotated locations for NP_001029040.1

      Status: VALIDATED

      Source sequence(s)
      BQ192594, CA339301, CB703892, CB812667, CK358924, CO558944
      UniProtKB/TrEMBL
      A6JTJ4, D4A1D8
      Related
      ENSRNOP00000065447.4, ENSRNOT00000071754.4
      Conserved Domains (1) summary
      pfam02077
      Location:4 → 269
      SURF4; SURF4 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      30646435..30659641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592017.3 → XP_017447506.1  surfeit locus protein 4 isoform X1

      UniProtKB/TrEMBL
      D4A1D8
      Conserved Domains (1) summary
      cl21527
      Location:1 → 226
      DoxX
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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