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    Polr3gl polymerase (RNA) III (DNA directed) polypeptide G like [ Mus musculus (house mouse) ]

    Gene ID: 69870, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Polr3glprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide G likeprovided by MGI
    Primary source
    MGI:MGI:1917120
    See related
    Ensembl:ENSMUSG00000028104 AllianceGenome:MGI:1917120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010003I19Rik
    Summary
    Enables chromatin binding activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in alimentary system; eye; nervous system; retina; and stomach. Orthologous to human POLR3GL (RNA polymerase III subunit GL). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.3), bladder adult (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr3gl in Genome Data Viewer
    Location:
    3 F2.1; 3 41.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96485188..96501497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96577872..96594181, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene hemojuvelin BMP co-receptor Neighboring gene STARR-positive B cell enhancer mm9_chr3:96351291-96351592 Neighboring gene STARR-positive B cell enhancer ABC_E6082 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96361830-96361983 Neighboring gene STARR-seq mESC enhancer starr_08439 Neighboring gene predicted gene 15441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:96368663-96368826 Neighboring gene thioredoxin interacting protein Neighboring gene STARR-seq mESC enhancer starr_08441 Neighboring gene STARR-positive B cell enhancer ABC_E6083 Neighboring gene STARR-seq mESC enhancer starr_08442 Neighboring gene STARR-positive B cell enhancer ABC_E3451 Neighboring gene ankyrin repeat domain 34A Neighboring gene RIKEN cDNA 6330549D23 gene Neighboring gene predicted gene, 52628 Neighboring gene Lix1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development. Wang X, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32576691, Free PMC Article
    2. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7-like
    Names
    DNA-directed RNA polymerase III subunit G-like
    RNA polymerase III subunit C7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293701.1 → NP_001280630.1  DNA-directed RNA polymerase III subunit RPC7-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC122037
      Consensus CDS
      CCDS79982.1
      UniProtKB/TrEMBL
      D3YXS1
      Related
      ENSMUSP00000118943.2, ENSMUST00000145001.2

    2. NM_027241.4 → NP_081517.2  DNA-directed RNA polymerase III subunit RPC7-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122037, AK008069
      Consensus CDS
      CCDS17641.1
      UniProtKB/Swiss-Prot
      Q8R0C0, Q9D8G0
      Related
      ENSMUSP00000089544.4, ENSMUST00000091924.10
      Conserved Domains (1) summary
      pfam11705
      Location:21 → 201
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      96485188..96501497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252811.2 → XP_030108671.1  DNA-directed RNA polymerase III subunit RPC7-like isoform X1

      UniProtKB/Swiss-Prot
      Q8R0C0, Q9D8G0
      Conserved Domains (1) summary
      pfam11705
      Location:21 → 201
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0C0.2 GenPept UniProtKB/Swiss-Prot:Q8R0C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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