Ighg1 immunoglobulin heavy constant gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ighg1provided by RGD
Official Full Name: immunoglobulin heavy constant gamma 1provided by RGD
Primary source: RGD:1359539
See related: AllianceGenome:RGD:1359539
Gene type: other
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ighg; RGD1359539
Summary: Predicted to enable Fc-gamma receptor I complex binding activity and antigen binding activity. Predicted to be involved in B cell differentiation; adaptive immune response; and complement-dependent cytotoxicity. Predicted to act upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be part of IgG immunoglobulin complex and immunoglobulin complex, circulating. Predicted to be active in cytoplasm. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

Location:: 6q32

Annotation release	Status	Assembly	Chr	Location
106	latest, but not current	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (139140572..139784388, complement)
106	latest, but not current	Rn_Celera (GCF_000002265.2)	6	AC_000074.1 (129920648..129922321, complement)

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Other Names

Ig gamma-1 chain C region
Immunoglobulin heavy chain (gamma polypeptide)

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antibacterial humoral response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type I hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013945.1: Suppressed sequence

Description

NM_001013945.1: This RefSeq was permanently suppressed because immunoglobulin and T-cell receptor loci are out of scope for RefSeq transcripts.