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    Hpgd 15-hydroxyprostaglandin dehydrogenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79242, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hpgdprovided by RGD
    Official Full Name
    15-hydroxyprostaglandin dehydrogenaseprovided by RGD
    Primary source
    RGD:620087
    See related
    EnsemblRapid:ENSRNOG00000010610 AllianceGenome:RGD:620087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 301.9), Kidney (RPKM 262.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Hpgd in Genome Data Viewer
    Location:
    16p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (38996876..39034831, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (33986265..34024228, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (37457134..37495758, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal oxygenase 2, pseudogene 4 Neighboring gene high-mobility group box 1, pseudogene 8 Neighboring gene ESF1 nucleolar pre-rRNA processing protein, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity  
    enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity PubMed 
    enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity  
    enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity  
    enables NAD binding  
    enables NAD binding  
    enables NAD+ binding  
    enables NAD+ binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  
    enables prostaglandin E receptor activity  
    enables prostaglandin E receptor activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in ductus arteriosus closure  
    involved_in ductus arteriosus closure  
    involved_in female pregnancy  
    involved_in female pregnancy PubMed 
    involved_in female pregnancy  
    involved_in female pregnancy  
    involved_in kidney development PubMed 
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell cycle  
    involved_in ovulation  
    involved_in parturition  
    involved_in parturition  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation PubMed 
    involved_in prostaglandin metabolic process  
    involved_in prostaglandin metabolic process PubMed 
    involved_in prostaglandin metabolic process  
    involved_in prostaglandin metabolic process  
    involved_in regulation of prostaglandin catabolic process  
    involved_in regulation of prostaglandin catabolic process  
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in thrombin-activated receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in basolateral plasma membrane  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular space PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Names
    15-PGDH
    NAD-dependent 15-hydroxyprostaglandin dehydrogenase
    PGDH
    eicosanoid/docosanoid dehydrogenase
    hydroxyprostaglandin dehydrogenase 15 (NAD)
    prostaglandin dehydrogenase 1
    NP_077366.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024390.3NP_077366.2  15-hydroxyprostaglandin dehydrogenase [NAD(+)]

      See identical proteins and their annotated locations for NP_077366.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      O08699, Q6P687
      UniProtKB/TrEMBL
      A6KIY1
      Related
      ENSRNOP00000014229.4, ENSRNOT00000014229.6
      Conserved Domains (1) summary
      cd05323
      Location:6254
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      38996876..39034831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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