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    PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]

    Gene ID: 5300, updated on 4-Jan-2025

    Summary

    Official Symbol
    PIN1provided by HGNC
    Official Full Name
    peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by HGNC
    Primary source
    HGNC:HGNC:8988
    See related
    Ensembl:ENSG00000127445 MIM:601052; AllianceGenome:HGNC:8988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOD; UBL5
    Summary
    Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in brain (RPKM 30.9), testis (RPKM 25.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PIN1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9835318..9849689)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9961482..9975854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9945994..9960365)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9938176-9938900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10048 Neighboring gene PIN1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9958151-9958702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9958703-9959252 Neighboring gene ubiquitin like 5 Neighboring gene olfactomedin 2 Neighboring gene uncharacterized LOC124904636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10046447-10047041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10047708-10048210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:10062835-10063428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10063429-10064021 Neighboring gene collagen type V alpha 3 chain Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10109314-10109542 Neighboring gene Sharpr-MPRA regulatory region 3549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10112173-10112674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10112675-10113174

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif(-) expression cooperates with Pin1 resulting in the reduction of A3G levels and the decreased incorporation of A3G into virions, suggesting the interaction between HIV-1 Vif and A3G PubMed
    capsid gag Phosphorylation of HIV-1 CA at serine residue 16 is involved in the HIV-1 core uncoating process. Interaction of PIN1 with the CA core within the target cells is required for the uncoating process PubMed
    integrase gag-pol HIV-1 IN is incapable of binding Pin1 Y23A mutant. The catalytically inactive Pin1 C113A mutant can bind HIV-1 IN, but completely ineffective at modifying IN sensitivity to subtilisin PubMed
    gag-pol Cellular Pin1 binds phosphorylated HIV-1 IN wild type and controls IN stability, but not S57A IN mutant PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ40239, FLJ77628, MGC10717

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activating protein binding PubMed 
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity  
    enables beta-catenin binding PubMed 
    enables beta-catenin binding  
    enables cis-trans isomerase activity PubMed 
    enables cytoskeletal motor activity  
    enables mitogen-activated protein kinase kinase binding PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity PubMed 
    enables phosphoprotein binding PubMed 
    enables phosphoserine residue binding PubMed 
    enables phosphothreonine residue binding PubMed 
    enables phosphothreonine residue binding PubMed 
    enables protein binding PubMed 
    enables tau protein binding PubMed 
    enables ubiquitin ligase activator activity PubMed 
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia PubMed 
    NOT involved_in microtubule polymerization PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of SMAD protein signal transduction PubMed 
    involved_in negative regulation of amyloid-beta formation PubMed 
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of cell motility PubMed 
    involved_in negative regulation of protein binding PubMed 
    involved_in negative regulation of protein catabolic process PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in neuron differentiation  
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of protein binding PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in protein peptidyl-prolyl isomerization PubMed 
    involved_in protein peptidyl-prolyl isomerization PubMed 
    involved_in protein stabilization PubMed 
    involved_in protein stabilization  
    involved_in protein targeting to mitochondrion PubMed 
    acts_upstream_of_or_within regulation of cytokinesis PubMed 
    acts_upstream_of_or_within regulation of cytokinesis PubMed 
    involved_in regulation of gene expression PubMed 
    involved_in regulation of mitotic nuclear division PubMed 
    involved_in regulation of protein localization to nucleus PubMed 
    involved_in regulation of protein phosphorylation PubMed 
    involved_in regulation of protein stability PubMed 
    involved_in response to hypoxia PubMed 
    involved_in synapse organization  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in ciliary basal body PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    located_in midbody PubMed 
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    is_active_in postsynaptic cytosol PubMed 

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    Names
    PPIase Pin1
    parvulin PIN1
    protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
    protein interacting with never in mitosis A1
    rotamase Pin1
    NP_006212.1
    XP_011526370.1
    XP_054177179.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029167.1 RefSeqGene

      Range
      5001..19483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_847

    mRNA and Protein(s)

    1. NM_006221.4 → NP_006212.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.
      Source sequence(s)
      AK291074, BI827672, CA439440
      Consensus CDS
      CCDS12220.1
      UniProtKB/Swiss-Prot
      A8K4V9, Q13526, Q53X75
      Related
      ENSP00000247970.5, ENST00000247970.9
      Conserved Domains (2) summary
      pfam00397
      Location:7 → 37
      WW; WW domain
      cl29122
      Location:51 → 162
      Rotamase_2; PPIC-type PPIASE domain

    RNA

    1. NR_038422.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
      Source sequence(s)
      BC002899, BI827672, CA439440, CD675162
    2. NR_038830.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon in the 5' region, resulting in a premature stop codon, and lacks a segment in the 3' region, compared to variant 1. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
      Source sequence(s)
      BC031971, BG912418, BI827672, CA439440, CD675162
      Related
      ENST00000590540.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9835318..9849689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528068.3 → XP_011526370.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

      Conserved Domains (3) summary
      COG0760
      Location:58 → 164
      SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam00397
      Location:25 → 42
      WW; WW domain
      cl08278
      Location:56 → 167
      Rotamase_2; PPIC-type PPIASE domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9961482..9975854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321204.1 → XP_054177179.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

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