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    MORN5 MORN repeat containing 5 [ Homo sapiens (human) ]

    Gene ID: 254956, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MORN5provided by HGNC
    Official Full Name
    MORN repeat containing 5provided by HGNC
    Primary source
    HGNC:HGNC:17841
    See related
    Ensembl:ENSG00000185681 MIM:619837; AllianceGenome:HGNC:17841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf18; C9orf113
    Summary
    Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 7.1), heart (RPKM 2.0) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MORN5 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122159908..122200083)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134357378..134397571)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124922187..124962362)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124887422-124888188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124888189-124888954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124888955-124889721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124889722-124890487 Neighboring gene microRNA 4478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124896063-124896602 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124896718-124897622 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8 Neighboring gene Sharpr-MPRA regulatory region 3979 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:124962138-124962350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20240 Neighboring gene LIM homeobox 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124988963-124989468 Neighboring gene MPRA-validated peak7328 silencer Neighboring gene RNA binding motif protein 18 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:125026651-125027850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
    2. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of smoking behaviours among Bangladeshi adults.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46909, FLJ50034

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MORN repeat-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286828.2 → NP_001273757.1  MORN repeat-containing protein 5 isoform b

      See identical proteins and their annotated locations for NP_001273757.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AI560944, AK128877, BC143440, HY011325
      Consensus CDS
      CCDS75894.1
      UniProtKB/TrEMBL
      A0A0A0MTF6
      Related
      ENSP00000437483.2, ENST00000536616.5
      Conserved Domains (1) summary
      cl27415
      Location:5 → 62
      COG4642; Uncharacterized conserved protein [Function unknown]

    2. NM_198469.4 → NP_940871.2  MORN repeat-containing protein 5 isoform a

      See identical proteins and their annotated locations for NP_940871.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI560944, AK128877, BC133690, HY011325
      Consensus CDS
      CCDS6836.1
      UniProtKB/Swiss-Prot
      B7Z7I5, Q5VZ52, Q6ZQN1
      Related
      ENSP00000362869.3, ENST00000373764.8
      Conserved Domains (1) summary
      cl27415
      Location:5 → 76
      COG4642; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      122159908..122200083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      134357378..134397571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZ52.1 GenPept UniProtKB/Swiss-Prot:Q5VZ52

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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