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    Spast spastin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362700, updated on 4-Jan-2025

    Summary

    Official Symbol
    Spastprovided by RGD
    Official Full Name
    spastinprovided by RGD
    Primary source
    RGD:1308494
    See related
    EnsemblRapid:ENSRNOG00000027136 AllianceGenome:RGD:1308494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spg4
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule severing ATPase activity; and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including endoplasmic reticulum tubular network; microtubule cytoskeleton; and nucleus. Predicted to be active in microtubule cytoskeleton. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 91.0), Brain (RPKM 84.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Spast in Genome Data Viewer
    Location:
    6q13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (26807220..26858456, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (21055349..21106586, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (22230067..22282166, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene NLR family, CARD domain containing 4 Neighboring gene solute carrier family 30 member 6 Neighboring gene uncharacterized LOC103692563 Neighboring gene ribosomal protein L18A, pseudogene 5 Neighboring gene uncharacterized LOC120103480 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables isomerase activity  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule severing ATPase activity  
    enables microtubule severing ATPase activity  
    enables microtubule severing ATPase activity  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in anterograde axonal transport  
    involved_in anterograde axonal transport  
    involved_in anterograde axonal transport  
    involved_in axonal transport of mitochondrion  
    involved_in axonal transport of mitochondrion  
    involved_in axonal transport of mitochondrion  
    involved_in axonogenesis  
    involved_in cytokinetic process  
    involved_in cytokinetic process  
    involved_in cytokinetic process  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in membrane fission  
    involved_in membrane fission  
    involved_in membrane fission  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in microtubule severing  
    acts_upstream_of_or_within microtubule severing  
    involved_in microtubule severing  
    involved_in microtubule severing  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic spindle disassembly  
    involved_in mitotic spindle disassembly  
    involved_in mitotic spindle disassembly  
    involved_in nuclear membrane reassembly  
    involved_in nuclear membrane reassembly  
    involved_in nuclear membrane reassembly  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of microtubule depolymerization  
    involved_in protein hexamerization  
    involved_in protein hexamerization  
    involved_in protein hexamerization  
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    Items 1 - 25 of 44
    Items 1 - 20 of 39
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    located_in axon  
    located_in axon cytoplasm  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum tubular network  
    located_in endosome  
    located_in endosome  
    located_in endosome  
    located_in membrane  
    located_in microtubule  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in midbody  
    located_in midbody  
    located_in midbody  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in spindle  
    located_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  
    Items 1 - 20 of 39

    General protein information

    Preferred Names
    spastin
    Names
    spastic paraplegia 4 (autosomal dominant
    spastic paraplegia 4 (autosomal dominant; spastin)
    NP_001102172.2
    NP_001401883.1
    XP_008762708.1
    XP_008762710.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108702.3NP_001102172.2  spastin isoform 2

      See identical proteins and their annotated locations for NP_001102172.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      B2RYN7
      UniProtKB/TrEMBL
      A0A8L2QK18
      Related
      ENSRNOP00000085299.2, ENSRNOT00000105595.2
      Conserved Domains (5) summary
      smart00382
      Location:339475
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114192
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:343473
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:545577
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:306362
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001414954.1NP_001401883.1  spastin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K590, A0A8L2QK18
      Related
      ENSRNOP00000073338.2, ENSRNOT00000079137.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      26807220..26858456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764486.4XP_008762708.1  spastin isoform X1

      UniProtKB/TrEMBL
      A0A8L2QK18
      Related
      ENSRNOP00000099795.1, ENSRNOT00000159739.1
      Conserved Domains (5) summary
      smart00382
      Location:372508
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:376506
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:578610
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:339395
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_008764488.4XP_008762710.1  spastin isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3R4, A0A8L2QK18
      Conserved Domains (5) summary
      smart00382
      Location:340476
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:114193
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:344474
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:546578
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:307363
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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