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    Gusb glucuronidase, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24434, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gusbprovided by RGD
    Official Full Name
    glucuronidase, betaprovided by RGD
    Primary source
    RGD:2772
    See related
    EnsemblRapid:ENSRNOG00000000913 AllianceGenome:RGD:2772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gus-s; Ac2-223
    Summary
    Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 160.6), Liver (RPKM 123.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gusb in Genome Data Viewer
    Location:
    12q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32337281..32350838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26701188..26714718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30202066..30215583)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene ribosomal protein S9, pseudogene 15 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 Neighboring gene transfer RNA alanine (anticodon AGC) 84 Neighboring gene nuclear protein 2, transcriptional regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-glucuronidase activity  
    enables beta-glucuronidase activity PubMed 
    enables beta-glucuronidase activity  
    enables beta-glucuronidase activity PubMed 
    enables beta-glucuronidase activity  
    enables carbohydrate binding  
    enables carbohydrate binding PubMed 
    enables hydrolase activity  
    enables protein domain specific binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    is_active_in lysosomal lumen  
    located_in lysosome  
    is_active_in lysosome  
    located_in lysosome  

    General protein information

    Preferred Names
    beta-glucuronidase
    NP_058711.3
    XP_017453744.1
    XP_063127108.1
    XP_063127109.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017015.3NP_058711.3  beta-glucuronidase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P06760
      UniProtKB/TrEMBL
      F1LQQ8
      Related
      ENSRNOP00000001215.5, ENSRNOT00000001215.8
      Conserved Domains (1) summary
      cl30613
      Location:27627
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32337281..32350838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271039.1XP_063127109.1  beta-glucuronidase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZP5
      Related
      ENSRNOP00000084597.1, ENSRNOT00000103940.2
    2. XM_063271038.1XP_063127108.1  beta-glucuronidase isoform X1

    3. XM_017598255.3XP_017453744.1  beta-glucuronidase isoform X3

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