Rgs5 regulator of G-protein signaling 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs5provided by RGD
Official Full Name: regulator of G-protein signaling 5provided by RGD
Primary source: RGD:3568
See related: EnsemblRapid:ENSRNOG00000083506 AllianceGenome:RGD:3568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1671.0), Muscle (RPKM 867.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84381077..84417875)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (81848254..81885053)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (87966820..88002831)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AT1R activation results in translocation of RGS5 toward the plasma membrane, limiting AT1R-mediated vasoconstriction through its role in Gq/11 protein-dependent signaling.
Title: Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.
The enhancement of RGS5 activity by GPSM3 is maintained under these conditions.
Title: Regulation of RGS5 GAP activity by GPSM3.
Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure.
Title: Dlx1 and Rgs5 in the ductus arteriosus: vessel-specific genes identified by transcriptional profiling of laser-capture microdissected endothelial and smooth muscle cells.
RGS5 and VEGF coexpressed in the area of choroidal neovascularization, and RGS5 expressed later than VEGF.
Title: [Role and possible mechanism of regulators of G-protein signaling 5 in development of experimental choroidal neovascularization].
Results demonstrate that RGS5 expression is a critical mediator of both vascular smooth muscle contraction and potentially, arterial remodeling.
Title: PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.
After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs5, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling.
Title: RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy.
changes in common to caveolin-1 expression and G protein signalling, through attenuation of Rgs2 and Rgs5, may contribute to hypertension through augmentation of vasoconstrictor pathways
Title: Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets.
Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing
Title: Coexpression of Notch3 and Rgs5 in the pericyte-vascular smooth muscle cell axis in response to pulp injury.
role in regulating mitogen-activated protein kinase activation in rat vascular smooth muscle cells
Title: Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.

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General gene information

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Markers

AA817884 (e-PCR)
- UniSTS:249355

UniSTS:495957 (e-PCR)
- UniSTS:495957

Rgs5 (e-PCR), detects polymorphism
- UniSTS:495957

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019341.1 → NP_062214.1 regulator of G-protein signaling 5

See identical proteins and their annotated locations for NP_062214.1

Status: PROVISIONAL

Source sequence(s)

AF241259

UniProtKB/Swiss-Prot

P49800, Q9JKD7

UniProtKB/TrEMBL

A0A0G2JVF3, A5YN34

Related

ENSRNOP00000106997.1, ENSRNOT00000158021.1

Conserved Domains (1) summary

cd08717
Location:65 → 178

RGS_RGS5; Regulator of G protein signaling (RGS) domain found in the RGS5 protein