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    Nt5c3a 5'-nucleotidase, cytosolic IIIA [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312373, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nt5c3aprovided by RGD
    Official Full Name
    5'-nucleotidase, cytosolic IIIAprovided by RGD
    Primary source
    RGD:1312013
    See related
    EnsemblRapid:ENSRNOG00000005981 AllianceGenome:RGD:1312013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nt5c3
    Summary
    Enables 5'-nucleotidase activity. Involved in adenosine metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrion; and nuclear body. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 82.1), Spleen (RPKM 79.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nt5c3a in Genome Data Viewer
    Location:
    4q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (87491828..87534838, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (86161642..86204656, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (87238325..87281234, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 2 Neighboring gene FKBP prolyl isomerase 9 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 32 Neighboring gene vomeronasal 1 receptor 65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human erythrocyte pyrimidine 5'-nucleotidase, PN-I. Amici A, et al. Arch Biochem Biophys, 2002 Jan 15. PMID 11795870
    2. Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon. Amici A, et al. Blood, 2000 Aug 15. PMID 10942414
    3. Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides. Amici A, et al. FEBS Lett, 1997 Dec 15. PMID 9428647
    4. Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions. Rich SA, et al. J Biol Chem, 1996 Jan 12. PMID 8557639
    5. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, et al. J Neurochem, 2003 Apr. PMID 12675911

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenosine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic 5'-nucleotidase 3A
    Names
    5'-nucleotidase, cytosolic III
    cytosolic 5'-nucleotidase 3
    NP_001101332.1
    NP_001385770.1
    XP_006236612.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107862.2 → NP_001101332.1  cytosolic 5'-nucleotidase 3A isoform 2

      See identical proteins and their annotated locations for NP_001101332.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K097, A6K122, B2GUX5, F7ESB1
      Related
      ENSRNOP00000055497.2, ENSRNOT00000058703.4
      Conserved Domains (1) summary
      cl21460
      Location:16 → 295
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_001398841.1 → NP_001385770.1  cytosolic 5'-nucleotidase 3A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K097, A0A8I6AHB0, A6K120
      Related
      ENSRNOP00000093312.1, ENSRNOT00000097799.2
      Conserved Domains (1) summary
      cd07504
      Location:59 → 331
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      87491828..87534838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236550.5 → XP_006236612.1  cytosolic 5'-nucleotidase 3A isoform X1

      See identical proteins and their annotated locations for XP_006236612.1

      UniProtKB/TrEMBL
      A0A0G2K097, A6K122, B2GUX5, F7ESB1
      Conserved Domains (1) summary
      cl21460
      Location:16 → 295
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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