Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj16provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 16provided by RGD
Primary source: RGD:61824
See related: EnsemblRapid:ENSRNOG00000004713 AllianceGenome:RGD:61824
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kir5.1
Summary: Predicted to enable inward rectifier potassium channel activity. Involved in potassium ion transport; regulation of pH; and response to carbon dioxide. Located in basolateral plasma membrane. Used to study hypokalemia and metabolic acidosis. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1043.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (96489329..96520745)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (95990009..96021356)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (99330894..99391551)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of a novel variant in KCNJ16, encoding Kir5.1 channel.
Title: Characterization of a novel variant in KCNJ16, encoding K(ir)5.1 channel.
Repeated seizures lead to progressive ventilatory dysfunction in SS[Kcnj16-/-] rats.
Title: Repeated seizures lead to progressive ventilatory dysfunction in SS(Kcnj16-/-) rats.
Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
Title: Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
Knockout of Kcnj16 markedly altered RAAS regulation and function, suggesting Kir5.1 as a key regulator of the renin-angiotensin-aldosterone system , particularly when exposed to changes in dietary sodium and potassium content.
Title: Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.
results demonstrate that Kir5.1 channels are key regulators of renal salt handling in salt-sensitive hypertension
Title: Essential role of Kir5.1 channels in renal salt handling and blood pressure control.
Heteromeric Kir4.1-Kir5.1 channels confer pH sensitivity to retrotrapezoid nucleus astrocytes.
Title: Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism.
examined the heteromeric assembly of Kir5.1 with other Kir subunits and have shown that this subunit exhibits a highly selective interaction with members of the Kir4.0 subfamily and does not physically associate with other Kir subunits
Title: Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
data suggest the signals on the COOH terminus of Kir4.1 potassium channel determine the intracellular localization of Kir5.1 potassium channel/Kir4.1 heteromer in distal tubules
Title: PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules.
Specific immunoreactivity for Kir5.1 was detected in fibrocytes of the cochlear spiral ligament and spiral limbus, all of which are directly involved in K+ circulation.
Title: Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inward rectifier potassium channel 16

Names: BIR9; inward rectifier K(+) channel Kir5.1; potassium channel, inwardly rectifying subfamily J member 16; potassium voltage-gated channel subfamily J member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053314.3 → NP_445766.2 inward rectifier potassium channel 16

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P52191, Q9JI87

UniProtKB/TrEMBL

A0A8I5ZPC6, Q68G21

Conserved Domains (2) summary

pfam01007
Location:37 → 173

IRK; Inward rectifier potassium channel

pfam17655
Location:182 → 349

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

96489329..96520745

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247570.4 → XP_006247632.1 inward rectifier potassium channel 16 isoform X1

UniProtKB/Swiss-Prot

P52191, Q9JI87

UniProtKB/TrEMBL

A0A8I5ZPC6, Q68G21

Related

ENSRNOP00000089334.1, ENSRNOT00000095753.2

Conserved Domains (2) summary

pfam01007
Location:37 → 173

IRK; Inward rectifier potassium channel

pfam17655
Location:182 → 349

IRK_C; Inward rectifier potassium channel C-terminal domain