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    Ppcs phosphopantothenoylcysteine synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppcsprovided by RGD
    Official Full Name
    phosphopantothenoylcysteine synthetaseprovided by RGD
    Primary source
    RGD:1311399
    See related
    EnsemblRapid:ENSRNOG00000008572 AllianceGenome:RGD:1311399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311399
    Summary
    Predicted to enable phosphopantothenate--cysteine ligase activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA biosynthetic process; coenzyme A biosynthetic process; and heart process. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 123.0), Kidney (RPKM 96.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppcs in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138308394..138312047, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (133023077..133026899, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138466298..138470108, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486980 Neighboring gene coiled-coil domain containing 30 Neighboring gene transfer RNA alanine (anticodon AGC) 98 Neighboring gene zinc finger, MYND-type containing 12 Neighboring gene ribosomal modification protein rimK-like family member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
    2. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116383

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopantothenate--cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantothenate--cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphopantothenate--cysteine ligase
    NP_001034099.2
    XP_008762220.1
    XP_008762221.1
    XP_063143501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039010.2 → NP_001034099.2  phosphopantothenate--cysteine ligase

      See identical proteins and their annotated locations for NP_001034099.2

      Status: VALIDATED

      Source sequence(s)
      BG378487, BQ195046, CK474267
      UniProtKB/TrEMBL
      A6JZP0, D4A6X7
      Related
      ENSRNOP00000011392.4, ENSRNOT00000011392.8
      Conserved Domains (1) summary
      cl04410
      Location:37 → 285
      DFP; DNA / pantothenate metabolizm flavoprotein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      138308394..138312047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763998.3 → XP_008762220.1  phosphopantothenate--cysteine ligase isoform X1

      See identical proteins and their annotated locations for XP_008762220.1

      UniProtKB/TrEMBL
      A6JZP1
      Conserved Domains (1) summary
      PRK05579
      Location:5 → 128
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

    2. XM_008763999.4 → XP_008762221.1  phosphopantothenate--cysteine ligase isoform X1

      See identical proteins and their annotated locations for XP_008762221.1

      UniProtKB/TrEMBL
      A6JZP1
      Conserved Domains (1) summary
      PRK05579
      Location:5 → 128
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

    3. XM_063287431.1 → XP_063143501.1  phosphopantothenate--cysteine ligase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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