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    Sorcs3 sortilin-related VPS10 domain containing receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294043, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sorcs3provided by RGD
    Official Full Name
    sortilin-related VPS10 domain containing receptor 3provided by RGD
    Primary source
    RGD:1310974
    See related
    EnsemblRapid:ENSRNOG00000028832 AllianceGenome:RGD:1310974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within learning; memory; and regulation of long-term synaptic depression. Predicted to be located in postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 56.6), Kidney (RPKM 4.8) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Sorcs3 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (257040442..257675259)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (247099178..247734027)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267986305..268620331)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 58 Neighboring gene ribosomal protein L21 like 7 Neighboring gene transfer RNA lysine (anticodon CUU) 1 Neighboring gene uncharacterized LOC120100051 Neighboring gene transfer RNA lysine (anticodon CUU) 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485243 Neighboring gene uncharacterized LOC120100052

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in glutamatergic synapse  
    located_in postsynaptic density  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  

    General protein information

    Preferred Names
    VPS10 domain-containing receptor SorCS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106367.3NP_001099837.2  VPS10 domain-containing receptor SorCS3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4A2I9
      Related
      ENSRNOP00000059656.4, ENSRNOT00000065001.5
      Conserved Domains (3) summary
      smart00602
      Location:216814
      VPS10; VPS10 domain
      pfam00801
      Location:828901
      PKD; PKD domain
      pfam15901
      Location:658814
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      257040442..257675259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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