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    Mlana melan-A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293890, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mlanaprovided by RGD
    Official Full Name
    melan-Aprovided by RGD
    Primary source
    RGD:1306525
    See related
    EnsemblRapid:ENSRNOG00000036608 AllianceGenome:RGD:1306525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. Orthologous to human MLANA (melan-A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 11.8) and Uterus (RPKM 7.3) See more
    Orthologs
    NEW
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    Genomic context

    See Mlana in Genome Data Viewer
    Location:
    1q52
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236883075..236897693)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227469537..227483343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247869756..247883558)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100017 Neighboring gene uncharacterized LOC120100018 Neighboring gene bromodomain containing 10 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene RAN binding protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    melanoma antigen recognized by T-cells 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106348.1NP_001099818.1  melanoma antigen recognized by T-cells 1

      See identical proteins and their annotated locations for NP_001099818.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6I0X0, D3ZWI9
      Related
      ENSRNOP00000051645.2, ENSRNOT00000054764.5
      Conserved Domains (1) summary
      pfam14991
      Location:2116
      MLANA; Protein melan-A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      236883075..236897693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287038.1XP_063143108.1  melanoma antigen recognized by T-cells 1 isoform X1

      UniProtKB/TrEMBL
      A6I0X0, D3ZWI9