Ddx50 DExD-box helicase 50 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddx50provided by RGD
Official Full Name: DExD-box helicase 50provided by RGD
Primary source: RGD:1310934
See related: EnsemblRapid:ENSRNOG00000000396 AllianceGenome:RGD:1310934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in plasma membrane. Predicted to be active in nucleolus. Orthologous to human DDX50 (DExD-box helicase 50). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 218.7), Heart (RPKM 178.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31104354..31133652, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30561623..30591324, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32239736..32269522, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BF389733 (e-PCR)
- UniSTS:245524

d4rat71 (e-PCR)
- UniSTS:122035

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX50

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD-box helicase 50

NP_001013216.2

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013198.2 → NP_001013216.2 ATP-dependent RNA helicase DDX50

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I6AUH3, A6K459, D3ZG48

Related

ENSRNOP00000000446.7, ENSRNOT00000000446.8

Conserved Domains (3) summary

COG0513
Location:130 → 608

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd12936
Location:565 → 656

GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

cd17944
Location:145 → 346

DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50