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    Ust uronyl-2-sulfotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ustprovided by RGD
    Official Full Name
    uronyl-2-sulfotransferaseprovided by RGD
    Primary source
    RGD:1304743
    See related
    EnsemblRapid:ENSRNOG00000016381 AllianceGenome:RGD:1304743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sulfotransferase activity. Predicted to act upstream of or within establishment of cell polarity and regulation of axonogenesis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human UST (uronyl 2-sulfotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 50.6), Heart (RPKM 48.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ust in Genome Data Viewer
    Location:
    1p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (4487316..4782579, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2666983..2962276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (2330631..2627654, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 2 Neighboring gene ETS variant transcription factor 5, pseudogene 1 Neighboring gene uncharacterized LOC108348767 Neighboring gene uncharacterized LOC134482574 Neighboring gene fibrillarin, pseudogene 8 Neighboring gene RNA, U6 small nuclear 884

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation. Properzi F, et al. Eur J Neurosci, 2008 Feb. PMID 18279312
    2. Opposing functions of chondroitin sulfate and heparan sulfate during early neuronal polarization. Nishimura K, et al. Neuroscience, 2010 Sep 15. PMID 20600662
    3. Mutation burden analysis of six common mental disorders in African Americans by whole genome sequencing. Liu Y, et al. Hum Mol Genet, 2022 Nov 10. PMID 35642741
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The major injury-related change, seen in injured brain and cultured glia, was an increase in 2-O-sulphated HS and increased syndecan-1, suggesting novel approaches to modulating scar formation.
      Title: Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chondroitin 2-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dermatan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uronyl 2-sulfotransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108458.1 → NP_001101928.1  uronyl 2-sulfotransferase

      See identical proteins and their annotated locations for NP_001101928.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473994
      UniProtKB/TrEMBL
      A6JP23, D3ZPB6
      Related
      ENSRNOP00000022003.5, ENSRNOT00000022003.7
      Conserved Domains (1) summary
      cl22970
      Location:105 → 357
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      4487316..4782579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265960.1 → XP_063122030.1  uronyl 2-sulfotransferase isoform X1

      Related
      ENSRNOP00000103555.1, ENSRNOT00000154161.1

    2. XM_039081060.2 → XP_038936988.1  uronyl 2-sulfotransferase isoform X3

      Conserved Domains (1) summary
      cl22970
      Location:31 → 282
      Sulfotransfer_2; Sulfotransferase family

    3. XM_039081058.2 → XP_038936986.1  uronyl 2-sulfotransferase isoform X2

      Conserved Domains (1) summary
      cl22970
      Location:106 → 244
      Sulfotransfer_2; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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