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    Zbtb32 zinc finger and BTB domain containing 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb32provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 32provided by RGD
    Primary source
    RGD:1584121
    See related
    EnsemblRapid:ENSRNOG00000042465 AllianceGenome:RGD:1584121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within T cell proliferation; hemopoiesis; and regulation of cytokine production. Predicted to be located in nuclear chromosome. Orthologous to human ZBTB32 (zinc finger and BTB domain containing 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 46.6), Spleen (RPKM 13.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb32 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94969374..94978553, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85841931..85851116, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89043121..89052863, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1 Neighboring gene lysine methyltransferase 2B Neighboring gene microRNA 3569 Neighboring gene uroplakin 1A Neighboring gene cytochrome c oxidase subunit 6B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and DNA binding characteristics of the three-Cys(2)His(2) domain of mouse testis zinc finger protein. Chou CC, et al. Proteins, 2010 Aug 1. PMID 20544958
    2. ROG, repressor of GATA, regulates the expression of cytokine genes. Miaw SC, et al. Immunity, 2000 Mar. PMID 10755619
    3. Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Piazza F, et al. Mol Cell Biol, 2004 Dec. PMID 15542853, Free PMC Article
    4. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109517.1 → NP_001102987.1  zinc finger and BTB domain-containing protein 32

      See identical proteins and their annotated locations for NP_001102987.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6JA02, D4A2U2
      Related
      ENSRNOP00000059222.1, ENSRNOT00000063808.4
      Conserved Domains (3) summary
      COG5048
      Location:272 → 418
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:370 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:13 → 112
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94969374..94978553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589734.3 → XP_017445223.1  zinc finger and BTB domain-containing protein 32 isoform X1

      UniProtKB/TrEMBL
      A6JA02, D4A2U2
      Conserved Domains (3) summary
      COG5048
      Location:272 → 418
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:370 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:13 → 112
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_017589736.3 → XP_017445225.1  zinc finger and BTB domain-containing protein 32 isoform X3

    3. XM_063274403.1 → XP_063130473.1  zinc finger and BTB domain-containing protein 32 isoform X2

    4. XM_039091211.2 → XP_038947139.1  zinc finger and BTB domain-containing protein 32 isoform X1

      UniProtKB/TrEMBL
      A6JA02, D4A2U2
      Conserved Domains (3) summary
      COG5048
      Location:272 → 418
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:370 → 390
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:13 → 112
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    5. XM_008759188.3 → XP_008757410.1  zinc finger and BTB domain-containing protein 32 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:143 → 163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:141 → 163
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:156 → 177
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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