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    Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hsd17b1provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 1provided by RGD
    Primary source
    RGD:2836
    See related
    EnsemblRapid:ENSRNOG00000019830 AllianceGenome:RGD:2836
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    17BHD1
    Summary
    Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid biosynthetic process. Predicted to be active in cytosol. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 31.2), Uterus (RPKM 23.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsd17b1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86510011..86512211)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86009728..86011928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88987558..88989758)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit a1 Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene Coenzyme A synthase Neighboring gene PSMC3 interacting protein Neighboring gene MAX dimerization protein MLX

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Ghersevich S, et al. Endocrinology, 1994 Oct. PMID 7925110
    2. Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts. Akinola LA, et al. Gene, 1998 Feb 27. PMID 9524272
    3. 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Suzuki T, et al. Br J Cancer, 2000 Feb. PMID 10682658, Free PMC Article
    4. Reaction mechanism of 17-beta-estradiol dehydrogenase determined by equilibrium rate exchange. Betz G. J Biol Chem, 1971 Apr 10. PMID 4396689
    5. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, et al. Endocrinology, 1996 May. PMID 8612487

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
      Title: Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to metal ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in estrogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in testosterone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in testosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    estradiol 17-beta-dehydrogenase 1
    Names
    17-beta-HSD 1
    17-beta-hydroxysteroid dehydrogenase type 1
    Hydroxysteroid dehydrogenase 17 beta, type 1
    NP_036983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012851.2 → NP_036983.1  estradiol 17-beta-dehydrogenase 1

      See identical proteins and their annotated locations for NP_036983.1

      Status: PROVISIONAL

      Source sequence(s)
      X97754
      UniProtKB/Swiss-Prot
      P51657
      UniProtKB/TrEMBL
      A6HJ77
      Related
      ENSRNOP00000026878.5, ENSRNOT00000026878.7
      Conserved Domains (1) summary
      cl21454
      Location:4 → 260
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86510011..86512211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51657.1 GenPept UniProtKB/Swiss-Prot:P51657

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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