G6pc1 glucose-6-phosphatase catalytic subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: G6pc1provided by RGD
Full Name: glucose-6-phosphatase catalytic subunit 1provided by RGD
Primary source: RGD:2644
See related: EnsemblRapid:ENSRNOG00000053448 AllianceGenome:RGD:2644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: G6pc; Psme3; G6Pase
Summary: Enables glucose-6-phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to resveratrol. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of proteasome activator complex. Predicted to be active in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in glycogen storage disease Ia and hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1591.1) and Liver (RPKM 1555.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86807659..86819023)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86307400..86318766)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89286009..89296213)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrate an essential role for fructose 2,6-bisphosphate in the induction of glucose-6-phosphatase and other ChREBP target genes
Title: Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
An increase in G6Pase activity was observed in liver microsomes from rats starved overnight, which presented a ~15% decrease in hepatic Mg(2+) content.
Title: Enhanced glucose 6-phosphatase activity in liver of rats exposed to Mg(2+)-deficient diet.
Calorie restriction can inhibit the expressions of FoxO1, PEPCK and G-6-P, strengthen insulin signal conduction, suppress gluconeogenesis and thus regulate glycometabolism.
Title: [The effect of calorie restriction on the expression of liver's gluconeogenesis genes of rats fed a high fat diet].
The lower sensitivity of the liver nuclear envelope G-6-Pase to N-ethylmaleimide suggests that the catalytic subunit of this system has some differences from the microsomal isoform.
Title: [Glucose-6-phosphatase from nuclear envelope in rat liver].
The effect, which is lost when G6P has readily access to the ER lumen, requires physiological endoplasmic reticulum Mg(2+) content.
Title: Biphasic effect of extra-reticular Mg2+ on hepatic G6P transport and hydrolysis.
A novel chimeric promoter, consisting of a 1.6 kb glucose 6-phosphatase promoter and a segment of the regulatory element derived from the L-type pyruvate kinase promoter, was designed to provide strong and tight control of insulin expression in liver.
Title: Coupling of glucose response element from L-type pyruvate kinase and G6Pase promoter enhances glucose responsive activity in hepatoma cells.
kinetic properties of the glucose 6-phosphatase of liver microsomes in adjuvant arthritis
Title: Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats.
Multiple, distinct cis-regulatory promoter elements are involved in the glucose response of the rat G-6-Pase gene.
Title: The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
glucose 6-phosphatase has a role in the small intestine in the control of glucose homeostasis [review]
Title: A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis.
HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine
Title: Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129533 (e-PCR)
- UniSTS:212835

RH94788 (e-PCR)
- UniSTS:120035

Potential readthrough

Included genes: Aoc3, Psme3, Aoc2-ps1

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables glucose-6-phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables phosphotransferase activity, alcohol group as acceptor	ISO Inferred from Sequence Orthology more info
enables primary methylamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	TAS Traceable Author Statement more info	PubMed
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose-6-phosphate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to resveratrol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within steroid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose-6-phosphatase catalytic subunit 1

Names: G-6-Pase; glucose-6-phosphatase, catalytic subunit; proteasome activator subunit 3

NP_037230.2

EC 3.1.3.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013098.2 → NP_037230.2 glucose-6-phosphatase catalytic subunit 1

See identical proteins and their annotated locations for NP_037230.2

Status: VALIDATED

Source sequence(s)

BC090067

UniProtKB/Swiss-Prot

P43428, Q5FVC9

UniProtKB/TrEMBL

A0A8L2QF08, A6HJB1

Related

ENSRNOP00000071453.1, ENSRNOT00000085831.3

Conserved Domains (1) summary

cd03381
Location:42 → 280

PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...