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    Tmprss7 transmembrane serine protease 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288118, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmprss7provided by RGD
    Official Full Name
    transmembrane serine protease 7provided by RGD
    Primary source
    RGD:1304655
    See related
    EnsemblRapid:ENSRNOG00000002145 AllianceGenome:RGD:1304655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Orthologous to human TMPRSS7 (transmembrane serine protease 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 8.1) and Adrenal (RPKM 0.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmprss7 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68583710..68629200)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55127992..55166597)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60102125..60138065)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 10, depalmitoylase Neighboring gene transgelin 3 Neighboring gene similar to human chromosome 3 open reading frame 52 Neighboring gene germinal center-associated, signaling and motility

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transmembrane protease serine 7
    Names
    matriptase-3
    transmembrane protease, serine 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105882.2NP_001099352.2  transmembrane protease serine 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P86091
      UniProtKB/TrEMBL
      R9PXY0
      Conserved Domains (5) summary
      smart00020
      Location:591821
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:257345
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:470504
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:592823
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:94190
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      68583710..68629200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270393.1XP_063126463.1  transmembrane protease serine 7 isoform X2

      UniProtKB/Swiss-Prot
      P86091
      Related
      ENSRNOP00000112005.1, ENSRNOT00000167958.1
    2. XM_063270394.1XP_063126464.1  transmembrane protease serine 7 isoform X3

      UniProtKB/Swiss-Prot
      P86091
      Related
      ENSRNOP00000041453.5, ENSRNOT00000045521.7
    3. XM_039088183.2XP_038944111.1  transmembrane protease serine 7 isoform X1

      UniProtKB/Swiss-Prot
      P86091
      Related
      ENSRNOP00000099279.1, ENSRNOT00000152634.1
      Conserved Domains (4) summary
      smart00020
      Location:591821
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:257345
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:470504
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01390
      Location:94198
      SEA; SEA domain
    4. XM_039088187.2XP_038944115.1  transmembrane protease serine 7 isoform X8

      Conserved Domains (3) summary
      cd00041
      Location:257345
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:470504
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01390
      Location:94198
      SEA; SEA domain
    5. XM_039088188.2XP_038944116.1  transmembrane protease serine 7 isoform X10

      Conserved Domains (2) summary
      cd00041
      Location:257345
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01390
      Location:94198
      SEA; SEA domain
    6. XM_063270395.1XP_063126465.1  transmembrane protease serine 7 isoform X4

    7. XM_039088184.2XP_038944112.1  transmembrane protease serine 7 isoform X5

      Conserved Domains (3) summary
      smart00020
      Location:408638
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:74162
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:287321
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    8. XM_039088186.2XP_038944114.1  transmembrane protease serine 7 isoform X7

      Conserved Domains (3) summary
      smart00020
      Location:334564
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:288
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:213247
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    9. XM_039088185.2XP_038944113.1  transmembrane protease serine 7 isoform X6

      Conserved Domains (3) summary
      smart00020
      Location:376606
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:42130
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:255289
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    10. XM_063270396.1XP_063126466.1  transmembrane protease serine 7 isoform X9

    RNA

    1. XR_010055941.1 RNA Sequence

    2. XR_010055940.1 RNA Sequence

    3. XR_005491007.2 RNA Sequence