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    Rplp2 ribosomal protein lateral stalk subunit P2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140662, updated on 9-Dec-2024

    Summary

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    Symbol
    Rplp2provided by RGD
    Full Name
    ribosomal protein lateral stalk subunit P2provided by RGD
    Primary source
    RGD:621775
    See related
    EnsemblRapid:ENSRNOG00000068445 AllianceGenome:RGD:621775
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RP2
    Summary
    Enables iron ion binding activity and ribonucleoprotein complex binding activity. Involved in cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3072.5), Thymus (RPKM 2585.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rplp2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205975598..205978192)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196546086..196548636)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214428280..214430551)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 22 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ribosomal protein P2, a novel iron-binding protein. Furukawa T, et al. Arch Biochem Biophys, 1992 Oct. PMID 1524426
    2. The structure of a gene containing introns and encoding rat ribosomal protein P2. Chan YL, et al. Nucleic Acids Res, 1991 Sep 25. PMID 1923757, Free PMC Article
    3. The primary structure of the acidic phosphoprotein P2 from rat liver 60 S ribosomal subunits. Comparison with ribosomal 'A' proteins from other species. Lin A, et al. J Biol Chem, 1982 Aug 10. PMID 7096359
    4. A specific role for the phosphorylation of mammalian acidic ribosomal protein P2. Vard C, et al. J Biol Chem, 1997 Aug 8. PMID 9242705
    5. Thyrotropin stimulates the expression of an acidic ribosomal protein, P0, messenger ribonucleic acid in cultured rat thyroid (FRTL) cells. Ikeda M, et al. Endocrinology, 1991 May. PMID 1850354

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ribosomal protein P2 has been established as a novel nonreceptor substrate for G protein-coupled receptor kinase 2.
      Title: Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to Thyroid stimulating hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to cAMP IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytoplasmic translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein P2
    Names
    60S acidic ribosomal protein P2
    60S acidic ribosomal protein P2-like
    ribosomal protein P2
    ribosomal protein, large P2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030021.1 → NP_001025192.1  large ribosomal subunit protein P2

      See identical proteins and their annotated locations for NP_001025192.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099697
      UniProtKB/Swiss-Prot
      P02401, Q499W9
      UniProtKB/TrEMBL
      A6HXX9
      Related
      ENSRNOP00000097047.1, ENSRNOT00000109157.2
      Conserved Domains (1) summary
      cd05833
      Location:1 → 66
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205975598..205978192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081345.2 → XP_038937273.1  large ribosomal subunit protein P2 isoform X1

      Conserved Domains (1) summary
      cd05833
      Location:1 → 66
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02401.2 GenPept UniProtKB/Swiss-Prot:P02401

    Gene LinkOut

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