Rnase9 ribonuclease A family member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnase9provided by RGD
Official Full Name: ribonuclease A family member 9provided by RGD
Primary source: RGD:1359501
See related: EnsemblRapid:ENSRNOG00000029516 AllianceGenome:RGD:1359501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to act upstream of or within positive regulation of flagellated sperm motility involved in capacitation. Orthologous to human RNASE9 (ribonuclease A family member 9 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 3.1), Spleen (RPKM 3.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26733051..26736605, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24259525..24263079, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (27964000..27968492, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The rat RNase9 mRNA was specifically expressed in the epididymis, especially in the caput and corpus, and exhibited an androgen-dependent expression pattern but was downregulated in an epididymitis animal model.
Title: RNase9, an androgen-dependent member of the RNase A family, is specifically expressed in the rat epididymis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of flagellated sperm motility involved in capacitation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive ribonuclease-like protein 9

Names: ribonuclease 9; ribonuclease, RNase A family, 9 (non-active); ribonuclease-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008561.2 → NP_001008561.1 inactive ribonuclease-like protein 9 precursor

See identical proteins and their annotated locations for NP_001008561.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KEC9, F7FI09, Q5QJV4, W0UVG5

Related

ENSRNOP00000042519.2, ENSRNOT00000040616.5

Conserved Domains (1) summary

cd00163
Location:55 → 181

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...