Uhmk1 U2AF homology motif kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uhmk1provided by RGD
Official Full Name: U2AF homology motif kinase 1provided by RGD
Primary source: RGD:2968
See related: EnsemblRapid:ENSRNOG00000002941 AllianceGenome:RGD:2968
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KIS; Kist
Summary: Enables enzyme binding activity; protein serine/threonine kinase activity; and splicing factor binding activity. Involved in peptidyl-serine phosphorylation. Located in cytoplasm and nucleus. Orthologous to human UHMK1 (U2AF homology motif kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 433.4), Lung (RPKM 326.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84929418..84949194, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (82396646..82416292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (88521625..88536728, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIS presents a different specificity for the UHM docking sites that are present in the N-terminal region of SF3b155, thus providing a new insight into the variety of interactions mediated by UHM domains.
Title: Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI171226 (e-PCR)
- UniSTS:250478

D1S3697 (e-PCR)
- UniSTS:474275

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IC Inferred by Curator more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables splicing factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in neuronal ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase Kist

Names: P-CIP2; PAM COOH-terminal interactor protein 2; U2AF homology motif (UHM) kinase 1; kinase interacting stathmin; kinase interacting with leukemia-associated gene (stathmin); kinase interacting with stathmin

NP_058989.1

EC 2.7.11.1

XP_038946264.1

EC 2.7.11.1

XP_063128093.1

EC 2.7.11.1

XP_063128094.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017293.2 → NP_058989.1 serine/threonine-protein kinase Kist

See identical proteins and their annotated locations for NP_058989.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63285

UniProtKB/TrEMBL

A6IDP0, R9PXR8

Related

ENSRNOP00000003950.3, ENSRNOT00000003950.6

Conserved Domains (2) summary

cd14020
Location:22 → 308

STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

cd12465
Location:318 → 405

RRM_UHMK1; RNA recognition motif (RRM) found in U2AF homology motif kinase 1 (UHMK1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

84929418..84949194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090336.2 → XP_038946264.1 serine/threonine-protein kinase Kist isoform X2

UniProtKB/TrEMBL

A0A8I5ZM84

Related

ENSRNOP00000079145.1, ENSRNOT00000114096.2

Conserved Domains (2) summary

cd12465
Location:229 → 316

RRM_UHMK1; RNA recognition motif (RRM) found in U2AF homology motif kinase 1 (UHMK1) and similar proteins

cl21453
Location:1 → 219

PKc_like; Protein Kinases, catalytic domain
XM_063272024.1 → XP_063128094.1 serine/threonine-protein kinase Kist isoform X3

UniProtKB/TrEMBL

A6IDN9
XM_063272023.1 → XP_063128093.1 serine/threonine-protein kinase Kist isoform X1

UniProtKB/TrEMBL

A0A8I5ZKY0

Related

ENSRNOP00000078491.1, ENSRNOT00000108843.2