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    Zc3h18 zinc finger CCCH-type containing 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h18provided by RGD
    Official Full Name
    zinc finger CCCH-type containing 18provided by RGD
    Primary source
    RGD:1303257
    See related
    EnsemblRapid:ENSRNOG00000028501 AllianceGenome:RGD:1303257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nhn1
    Summary
    Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.3), Kidney (RPKM 81.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zc3h18 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67344422..67388400)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50434864..50479855)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55197348..55241800)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein, multitype 1 Neighboring gene uncharacterized LOC120098606 Neighboring gene motilin receptor Neighboring gene interleukin 17C Neighboring gene cytochrome b-245 alpha chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells. Pabis M, et al. RNA, 2013 Aug. PMID 23793891, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA cap binding complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 18
    Names
    conserved nuclear protein Nhn1
    nuclear protein NHN1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434427.1 → NP_001421356.1  zinc finger CCCH domain-containing protein 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q6TQE1, Q6TQE2
      UniProtKB/TrEMBL
      A0A8L2QI36, A6IZR5

    2. NM_201416.2 → NP_958819.1  zinc finger CCCH domain-containing protein 18 isoform 2

      See identical proteins and their annotated locations for NP_958819.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8L2QI36, A6IZR4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67344422..67388400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255758.5 → XP_006255820.1  zinc finger CCCH domain-containing protein 18 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKJ5, A0A8I6GGF2
      Related
      ENSRNOP00000093359.1, ENSRNOT00000101747.2

    2. XM_006255759.5 → XP_006255821.1  zinc finger CCCH domain-containing protein 18 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QI36

    3. XM_006255760.5 → XP_006255822.1  zinc finger CCCH domain-containing protein 18 isoform X3

      UniProtKB/TrEMBL
      A0A140TAG3, A0A8I6GGF2
      Related
      ENSRNOP00000082197.2, ENSRNOT00000106092.2
      Conserved Domains (1) summary
      smart00356
      Location:246 → 274
      ZnF_C3H1; zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TQE1.1 GenPept UniProtKB/Swiss-Prot:Q6TQE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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