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    Dse dermatan sulfate epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dseprovided by RGD
    Official Full Name
    dermatan sulfate epimeraseprovided by RGD
    Primary source
    RGD:1305079
    See related
    EnsemblRapid:ENSRNOG00000000824 AllianceGenome:RGD:1305079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sart2
    Summary
    Predicted to enable chondroitin-glucuronate 5-epimerase activity. Predicted to be involved in chondroitin sulfate metabolic process and dermatan sulfate biosynthetic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome musculocontractural type 2. Orthologous to human DSE (dermatan sulfate epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 144.4), Lung (RPKM 65.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dse in Genome Data Viewer
    Location:
    20q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (26661326..26740011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26118194..26196889, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27703738..27784982, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene calcium homeostasis modulator family member 6 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 5 Neighboring gene uncharacterized LOC134483908 Neighboring gene GRIP and coiled-coil domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL. Nakao M, et al. J Immunol, 2000 Mar 1. PMID 10679095
    2. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2. Maccarana M, et al. J Biol Chem, 2006 Apr 28. PMID 16505484
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chondroitin-glucuronate 5-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dermatan sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dermatan-sulfate epimerase
    Names
    squamous cell carcinoma antigen recognized by T cells 2
    NP_001102403.1
    XP_008771122.1
    XP_017457191.1
    XP_017457193.1
    XP_038954832.1
    XP_038954833.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108933.1 → NP_001102403.1  dermatan-sulfate epimerase precursor

      See identical proteins and their annotated locations for NP_001102403.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474016
      UniProtKB/TrEMBL
      A0A0G2JU02, A6K3S9, B5DF19, F7EHL3
      Related
      ENSRNOP00000001093.5, ENSRNOT00000001093.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      26661326..26740011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772900.4 → XP_008771122.1  dermatan-sulfate epimerase isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU02
      Related
      ENSRNOP00000068909.3, ENSRNOT00000088287.3
      Conserved Domains (1) summary
      pfam16332
      Location:192 → 380
      DUF4962; Domain of unknown function (DUF4962)

    2. XM_039098904.2 → XP_038954832.1  dermatan-sulfate epimerase isoform X2

      UniProtKB/TrEMBL
      A0A0G2JU02, A6K3S9, B5DF19, F7EHL3

    3. XM_017601704.3 → XP_017457193.1  dermatan-sulfate epimerase isoform X4

    4. XM_039098905.2 → XP_038954833.1  dermatan-sulfate epimerase isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU02

    5. XM_017601702.3 → XP_017457191.1  dermatan-sulfate epimerase isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU02
    Nucleotide Protein Strain
    Heading Accession and Version

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