Epb42 erythrocyte membrane protein band 4.2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epb42provided by RGD
Official Full Name: erythrocyte membrane protein band 4.2provided by RGD
Primary source: RGD:1305306
See related: EnsemblRapid:ENSRNOG00000011649 AllianceGenome:RGD:1305306
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epb4.2
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within several processes, including hemoglobin metabolic process; multicellular organismal-level iron ion homeostasis; and spleen development. Predicted to be located in cortical cytoskeleton and membrane. Predicted to be part of ankyrin-1 complex. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 5. Orthologous to human EPB42 (erythrocyte membrane protein band 4.2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 316.2) and Heart (RPKM 12.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128433460..128451683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (107979709..107997932, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (112967095..112985318, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein 4.2

Names: erythrocyte protein band 4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108590.2 → NP_001102060.1 protein 4.2

See identical proteins and their annotated locations for NP_001102060.1

Status: PROVISIONAL

Source sequence(s)

BC168935

UniProtKB/TrEMBL

A0A8I5ZZB1, A6HPL9, B5DF57, F7F1R4

Related

ENSRNOP00000015556.4, ENSRNOT00000015556.8

Conserved Domains (3) summary

smart00460
Location:261 → 351

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:6 → 123

Transglut_N; Transglutaminase family

pfam00927
Location:586 → 684

Transglut_C; Transglutaminase family, C-terminal ig like domain