Loxl3 lysyl oxidase-like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Loxl3provided by RGD
Official Full Name: lysyl oxidase-like 3provided by RGD
Primary source: RGD:1311011
See related: EnsemblRapid:ENSRNOG00000061373 AllianceGenome:RGD:1311011
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable fibronectin binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; fibronectin fibril organization; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 32.1), Heart (RPKM 31.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117098358..117114673)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115540640..115556958)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (113866782..113883713)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis.
Title: LOXL3 Inhibits Autophagy of Chondrocytes by Activating Rheb in Osteoarthritis.
Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats.
Title: Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats.
Dual inhibition of LOXL2 and LOXL3 in a pulmonary fibrosis model was sufficient to normalize collagen fibrillogenesis, reduce tissue stiffness, and improve lung function in vivo.
Title: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.

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General gene information

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Markers

Loxl3 (e-PCR), detects polymorphism
- UniSTS:507975

RH128117 (e-PCR)
- UniSTS:211425

RH124140 (e-PCR)
- UniSTS:161004

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in fibronectin fibril organization	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in somite development	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysyl oxidase homolog 3

NP_001101336.1

EC 1.4.3.-

EC 1.4.3.13

XP_038963514.2

EC 1.4.3.-

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.