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    Lrrc17 leucine rich repeat containing 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502715, updated on 9-Dec-2024

    Summary

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    Symbol
    Lrrc17provided by RGD
    Full Name
    leucine rich repeat containing 17provided by RGD
    Primary source
    RGD:1560165
    See related
    EnsemblRapid:ENSRNOG00000012817 AllianceGenome:RGD:1560165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in bone marrow development and negative regulation of osteoclast differentiation. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRC17 (leucine rich repeat containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 61.7), Heart (RPKM 60.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc17 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14393632..14424048, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13501428..13531845, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10108184..10138652, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 10 Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORD86 Neighboring gene uncharacterized LOC134486551 Neighboring gene family with sequence similarity 185, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. Kim T, et al. J Biol Chem, 2009 May 29. PMID 19336404, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in bone marrow development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025155.2 → NP_001020326.1  leucine-rich repeat-containing protein 17 precursor

      See identical proteins and their annotated locations for NP_001020326.1

      Status: VALIDATED

      Source sequence(s)
      BC079098, DY314273
      UniProtKB/TrEMBL
      F7ESW9, Q6AYD0
      Related
      ENSRNOP00000017103.3, ENSRNOT00000017103.6
      Conserved Domains (4) summary
      sd00033
      Location:68 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:299 → 337
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:273 → 333
      LRR_8; Leucine rich repeat
      cl15307
      Location:168 → 204
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14393632..14424048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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