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    Fbxo42 F-box protein 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo42provided by RGD
    Official Full Name
    F-box protein 42provided by RGD
    Primary source
    RGD:1304787
    See related
    EnsemblRapid:ENSRNOG00000014305 AllianceGenome:RGD:1304787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 49.3), Kidney (RPKM 44.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo42 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158734165..158792560)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153451162..153509564)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159670662..159729070)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene uncharacterized LOC134487027 Neighboring gene uncharacterized LOC134487028 Neighboring gene ciliogenesis and planar polarity effector 2-like Neighboring gene ciliogenesis and planar polarity effector complex subunit 2 Neighboring gene uncharacterized LOC108351054 Neighboring gene Rho guanine nucleotide exchange factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395590.1 → NP_001382519.1  F-box only protein 42

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4AE47
      Related
      ENSRNOP00000019195.8, ENSRNOT00000019195.9
      Conserved Domains (5) summary
      PLN02772
      Location:228 → 315
      PLN02772; guanylate kinase
      sd00038
      Location:119 → 168
      Kelch; KELCH repeat [structural motif]
      pfam12937
      Location:47 → 82
      F-box-like
      pfam13415
      Location:130 → 182
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:229 → 268
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158734165..158792560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108691.1: Suppressed sequence

      Description
      NM_001108691.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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