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    Zbtb8b zinc finger and BTB domain containing 8b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb8bprovided by RGD
    Official Full Name
    zinc finger and BTB domain containing 8bprovided by RGD
    Primary source
    RGD:1562327
    See related
    EnsemblRapid:ENSRNOG00000026898 AllianceGenome:RGD:1562327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zbtb8; Zbtb8l; RGD1562327
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB8B (zinc finger and BTB domain containing 8B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 17.5), Liver (RPKM 4.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb8b in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147046150..147065961, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141765925..141781619, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147628566..147644209, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene diablo, IAP-binding mitochondrial protein like 1 Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 2 Neighboring gene BSD domain containing 1 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene family with sequence similarity 229, member A Neighboring gene testis-specific serine kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 8B
    Names
    zinc finger and BTB domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109265.1 → NP_001102735.1  zinc finger and BTB domain-containing protein 8B

      See identical proteins and their annotated locations for NP_001102735.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ISI8
      Conserved Domains (4) summary
      smart00225
      Location:25 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:331 → 351
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14 → 118
      BTB; BTB/POZ domain
      pfam13465
      Location:344 → 368
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      147046150..147065961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238967.4 → XP_006239029.1  zinc finger and BTB domain-containing protein 8B isoform X1

      UniProtKB/TrEMBL
      D3ZLP0
      Related
      ENSRNOP00000034741.5, ENSRNOT00000037106.6
      Conserved Domains (5) summary
      smart00225
      Location:58 → 155
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:357 → 431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:364 → 384
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:47 → 151
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 401
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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