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    Atp6v1e2 ATPase H+ transporting V1 subunit E2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp6v1e2provided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit E2provided by RGD
    Primary source
    RGD:1311680
    See related
    EnsemblRapid:ENSRNOG00000015566 AllianceGenome:RGD:1311680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in acrosomal vesicle. Predicted to be part of proton-transporting two-sector ATPase complex, catalytic domain. Orthologous to human ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 67.7), Thymus (RPKM 7.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v1e2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (13417046..13425628)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7667359..7673711)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10510370..10517059, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class F Neighboring gene ras homolog family member Q Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene transmembrane protein 247 Neighboring gene Egam-1N-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A proton pump ATPase with testis-specific E1-subunit isoform required for acrosome acidification. Sun-Wada GH, et al. J Biol Chem, 2002 May 17. PMID 11872743
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting two-sector ATPase complex, catalytic domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit E 2
    Names
    ATPase, H transporting, lysosomal V1 subunit E2
    ATPase, H+ transporting, V1 subunit E-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108979.1 → NP_001102449.1  V-type proton ATPase subunit E 2

      See identical proteins and their annotated locations for NP_001102449.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6H9F3, D3ZJ78
      Related
      ENSRNOP00000020845.4, ENSRNOT00000020845.7
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      13417046..13425628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262178.1 → XP_063118248.1  V-type proton ATPase subunit E 2 isoform X1

      UniProtKB/TrEMBL
      A6H9F3, D3ZJ78
      Related
      ENSRNOP00000108982.1, ENSRNOT00000172150.1

    2. XM_006239715.5 → XP_006239777.1  V-type proton ATPase subunit E 2 isoform X1

      See identical proteins and their annotated locations for XP_006239777.1

      UniProtKB/TrEMBL
      A6H9F3, D3ZJ78
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    3. XM_006239716.5 → XP_006239778.1  V-type proton ATPase subunit E 2 isoform X1

      See identical proteins and their annotated locations for XP_006239778.1

      UniProtKB/TrEMBL
      A6H9F3, D3ZJ78
      Related
      ENSRNOP00000106944.1, ENSRNOT00000168229.1
      Conserved Domains (2) summary
      COG1390
      Location:9 → 217
      NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
      pfam01991
      Location:18 → 216
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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