Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufa10provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase subunit A10provided by RGD
Primary source: RGD:727968
See related: EnsemblRapid:ENSRNOG00000016470 AllianceGenome:RGD:727968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ndufa10l
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Involved in response to xenobiotic stimulus. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 592.7), Muscle (RPKM 351.2) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (100454498..100490023, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (93007034..93041825, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (99617051..99651827, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ass spectrometric analysis revealed that the replacement of an aspartate residue with asparagine at amino acid position 120 was the biochemical difference between the two Ndufa10 isoforms
Title: Characterization of mitochondrial NADH dehydrogenase 1α subcomplex 10 variants in cardiac muscles from normal Wistar rats and spontaneously hypertensive rats: Implications in the pathogenesis of hypertension.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI548120 (e-PCR)
- UniSTS:243481

Ndufa10 (e-PCR), detects polymorphism
- UniSTS:527437

RH129838 (e-PCR)
- UniSTS:213126

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Names: CI-42kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10; NADH-ubiquinone oxidoreductase 42 kDa subunit; complex I-42kD

NP_955789.2

EC 1.6.99.3

EC 7.1.1.2

XP_008765607.1

EC 1.6.99.3

EC 7.1.1.2

XP_038940123.1

EC 1.6.99.3

EC 7.1.1.2

XP_063123776.1

EC 1.6.99.3

EC 7.1.1.2

XP_063123777.1

EC 1.6.99.3

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199495.4 → NP_955789.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor

See identical proteins and their annotated locations for NP_955789.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q561S0, Q80WE0

UniProtKB/TrEMBL

A0A8L2QBL2, A6JQU0

Related

ENSRNOP00000022089.7, ENSRNOT00000022089.8

Conserved Domains (1) summary

cd02030
Location:59 → 277

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

100454498..100490023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267707.1 → XP_063123777.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q561S0, Q80WE0

UniProtKB/TrEMBL

A0A8L2QBL2, A6JQU0
XM_063267706.1 → XP_063123776.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q561S0, Q80WE0

UniProtKB/TrEMBL

A0A8L2QBL2, A6JQU0
XM_039084195.2 → XP_038940123.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3

UniProtKB/TrEMBL

A6JQU3, Q6P6W6

Conserved Domains (1) summary

cd02030
Location:1 → 195

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
XM_008767385.4 → XP_008765607.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I6A6A5, A6JQU2

Related

ENSRNOP00000107866.1, ENSRNOT00000153949.1

Conserved Domains (1) summary

cd02030
Location:59 → 277

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...