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    Madcam1 mucosal vascular addressin cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Madcam1provided by RGD
    Official Full Name
    mucosal vascular addressin cell adhesion molecule 1provided by RGD
    Primary source
    RGD:3029
    See related
    AllianceGenome:RGD:3029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable integrin binding activity involved in cell-matrix adhesion. Involved in cell adhesion and positive regulation of leukocyte migration. Predicted to be located in plasma membrane. Used to study Crohn's disease and food allergy. Orthologous to human MADCAM1 (mucosal vascular addressin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 5.4), Brain (RPKM 4.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Madcam1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10686920..10690322, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10036301..10039703, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12918352..12922509, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 34, ubiqiutin conjugating enzyme Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene CIMAP1 family member D Neighboring gene SHC adaptor protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. Sugito K, et al. Transplant Proc, 2005 Dec. PMID 16387148
    2. Basis for the age-related decline in intestinal mucosal immunity. Schmucker DL, et al. Clin Dev Immunol, 2003 Jun-Dec. PMID 14768948, Free PMC Article
    3. Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1. Ogawa T, et al. Am J Physiol Gastrointest Liver Physiol, 2004 May. PMID 14670821
    4. Expression of adhesion molecules in the rectum-associated lymph nodules of pre- and postnatal specific pathogen-free rats. Ichikawa S, et al. J Gastroenterol Hepatol, 2003 Aug. PMID 12859728
    5. Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis. Cook HT, et al. Am J Pathol, 2002 Oct. PMID 12368200, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunohistochemical analysis of MAdCAM-1 expression during acute rejection on small bowel grafts in rats
      Title: Immunohistochemical analysis of MAdCAM-1 expression during acute rejection on small bowel grafts in rats.
    2. Treatment with an antibody to this antigen reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis
      Title: Treatment with an antibody to VLA-1 integrin reduces glomerular and tubulointerstitial scarring in a rat model of crescentic glomerulonephritis.
    3. Our model of chronic food allergy revealed that lymphocyte migration was increased with MAdCAM-1 upregulation.
      Title: Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1.
    4. During small bowel allograft rejection., FTY720 was found to prevent the down-regulation of MAdCAM-1 expression in endothelial venules
      Title: Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding involved in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding involved in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lymphocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucosal addressin cell adhesion molecule 1
    Names
    MAdCAM-1
    rMAdCAM-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019317.1 → NP_062190.1  mucosal addressin cell adhesion molecule 1 precursor

      See identical proteins and their annotated locations for NP_062190.1

      Status: PROVISIONAL

      Source sequence(s)
      D87840
      UniProtKB/Swiss-Prot
      O70540
      UniProtKB/TrEMBL
      A6K8Z4
      Conserved Domains (1) summary
      pfam09085
      Location:108 → 215
      Adhes-Ig_like; Adhesion molecule, immunoglobulin-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10686920..10690322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70540.1 GenPept UniProtKB/Swiss-Prot:O70540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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