Krt2 keratin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt2provided by RGD
Official Full Name: keratin 2provided by RGD
Primary source: RGD:1303297
See related: EnsemblRapid:ENSRNOG00000009563 AllianceGenome:RGD:1303297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kb2; CK 2e
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including keratinocyte activation; keratinocyte migration; and keratinocyte proliferation. Predicted to act upstream of or within keratinocyte development. Predicted to be located in cornified envelope and cytoplasm. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 17.9), Heart (RPKM 15.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (134819584..134826736, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (132940879..132948031, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143412858..143420463, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of skin epidermis	IEA Inferred from Electronic Annotation more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinization	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte activation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte activation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte migration	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermis development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermis development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermis development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 2 epidermal

Names: CK-2e; K2e; cytokeratin-2e; epithelial keratin-2e; keratin 2, type II; keratin-2 epidermis; keratin-2e; type II keratin Kb2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008899.2 → NP_001008899.2 keratin, type II cytoskeletal 2 epidermal

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2JWX4

Related

ENSRNOP00000070051.3, ENSRNOT00000082863.3

Conserved Domains (1) summary

pfam00038
Location:196 → 509

Filament; Intermediate filament protein